Alexander Medvinsky

Position:

Professor in Haematopoietic Stem Cell Biology

Telephone:

0131 651 9556

Display email:

a.medvinsky@ed.ac.uk

Publications

2019

Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo. Easterbrook, Jennifer, Rybtsov Stanislav, Gordon-Keylock Sabrina, Ivanovs Andrejs, Taoudi Samir, Anderson Richard A., and Medvinsky A L. , Stem Cell Reports, 2019 May 14, Volume 12, Issue 5, p.1056-1068, (2019)

2018

Cellular Origin and Functional Relevance of Collagen I Production in the Kidney. Buchtler, Simone, Grill Alexandra, Hofmarksrichter Stefanie, Stöckert Petra, Schiechl-Brachner Gabriela, Gomez Manuel Rodriguez, Neumayer Sophia, Schmidbauer Kathrin, Talke Yvonne, Klinkhammer Barbara M., et al. , J Am Soc Nephrol, 2018 Jul, Volume 29, Issue 7, p.1859-1873, (2018)

Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach. Senserrich, Jordi, Batsivari Antoniana, Rybtsov Stanislav, Gordon-Keylock Sabrina, Souilhol Céline, Buchholz Frank, Hills David, Zhao Suling, and Medvinsky A L. , Stem Cell Reports, 2018 Sep 11, Volume 11, Issue 3, p.784-794, (2018)

2017

Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture. Batsivari, Antoniana, Rybtsov Stanislav, Souilhol Céline, Binagui-Casas Anahí, Hills David, Zhao Suling, Travers Paul, and Medvinsky A L. , Stem Cell Reports, 2017 Jun 06, Volume 8, Issue 6, p.1549-1562, (2017)

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation. McGarvey, Alison C., Rybtsov Stanislav, Souilhol Céline, Tamagno Sara, Rice Ritva, Hills David, Godwin Duncan, Rice David, Tomlinson Simon R., and Medvinsky A L. , J Exp Med, 2017 Dec 04, Volume 214, Issue 12, p.3731-3751, (2017)

Human haematopoietic stem cell development: from the embryo to the dish. Ivanovs, Andrejs, Rybtsov Stanislav, Ng Elizabeth S., Stanley Edouard G., Elefanty Andrew G., and Medvinsky A L. , Development, 2017 Jul 01, Volume 144, Issue 13, p.2323-2337, (2017)

Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Redgrave, Rachael E., Tual-Chalot Simon, Davison Benjamin J., Singh Esha, Hall Darroch, Amirrasouli Muhammad M., Gilchrist Derek, Medvinsky A L., and Arthur Helen M. , Stem Cell Reports, 2017 May 09, Volume 8, Issue 5, p.1287-1298, (2017)

2016

Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies. Mirantes, Cristina, Dosil Maria Alba, Hills David, Yang Jian, Eritja Núria, Santacana Maria, Gatius Sònia, Vilardell Felip, Medvinsky A L., Matias-Guiu Xavier, et al. , Blood, 2016 Apr 14, Volume 127, Issue 15, p.1907-11, (2016)

Developing HSCs become Notch independent by the end of maturation in the AGM region. Souilhol, Céline, Lendinez Javier G., Rybtsov Stanislav, Murphy Fiona, Wilson Heather, Hills David, Batsivari Antoniana, Binagui-Casas Anahí, McGarvey Alison C., H MacDonald Robson, et al. , Blood, 2016 Sep 22, Volume 128, Issue 12, p.1567-77, (2016)

Blood flow controls bone vascular function and osteogenesis. Ramasamy, Saravana K., Kusumbe Anjali P., Schiller Maria, Zeuschner Dagmar, M Bixel Gabriele, Milia Carlo, Gamrekelashvili Jaba, Limbourg Anne, Medvinsky A L., Santoro Massimo M., et al. , Nat Commun, 2016 Dec 06, Volume 7, p.13601, (2016)

Ontogeny of the Hematopoietic System. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 1–14. Ciau-Uitz, A, Patient R, and Medvinsky A L. , Encyclopedia of Immunobiology, Volume Vol 1, Oxford, (2016)

Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver. Rybtsov, Stanislav, Ivanovs Andrejs, Zhao Suling, and Medvinsky A L. , Development, 2016 Apr 15, Volume 143, Issue 8, p.1284-9, (2016)

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. Souilhol, Céline, le Gonneau Christè, Lendinez Javier G., Batsivari Antoniana, Rybtsov Stanislav, Wilson Heather, Morgado-Palacin Lucia, Hills David, Taoudi Samir, Antonchuk Jennifer, et al. , Nat Commun, 2016, Volume 7, p.10784, (2016)

The European Hematology Association Roadmap for European Hematology Research. A Consensus Document. Engert, Andreas, Balduini Carlo, Brand Anneke, Coiffier Bertrand, Cordonnier Catherine, Döhner Hartmut, de Wit Thom Duyvene', Eichinger Sabine, Fibbe Willem, Green Tony, et al. , Haematologica, 2016 Jan 27, (2016)

2015

Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation. Economou, Constantinos, Tsakiridis Anestis, Wymeersch Filip J., Gordon-Keylock Sabrina, Dewhurst Robert E., Fisher Dawn, Medvinsky A L., Smith A G., and Wilson Valerie , BMC Dev Biol, 2015, Volume 15, Issue 1, p.35, (2015)

Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. Naillat, Florence, Yan Wenying, Karjalainen Riikka, Liakhovitskaia Anna, Samoylenko Anatoly, Xu Qi, Sun Zhandong, Shen Bairong, Medvinsky A L., Quaggin Susan, et al. , Exp Cell Res, 2015 Mar 15, Volume 332, Issue 2, p.163-78, (2015)

In search of human hematopoietic stem cell identity. Ivanovs, Andrejs, and Medvinsky A L. , Cell Stem Cell, 2015 Jan 8, Volume 16, Issue 1, p.5-6, (2015)

On human development: lessons from stem cell systems. Medvinsky, A L., and Livesey Frederick J. , Development, 2015 Jan 1, Volume 142, Issue 1, p.17-20, (2015)

2014

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Potts, Kathryn S., Sargeant Tobias J., Markham John F., Shi Wei, Biben Christine, Josefsson Emma C., Whitehead Lachlan W., Rogers Kelly L., Liakhovitskaia Anna, Smyth Gordon K., et al. , Blood, 2014 Oct 23, Volume 124, Issue 17, p.2725-9, (2014)

Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43(-) Embryonic Precursor. Rybtsov, Stanislav, Batsivari Antoniana, Bilotkach Kateryna, Paruzina Daria, Senserrich Jordi, Nerushev Oleg, and Medvinsky A L. , Stem Cell Reports, 2014 Sep 9, Volume 3, Issue 3, p.489-501, (2014)

Directed differentiation of embryonic stem cells using a bead-based combinatorial screening method. Tarunina, Marina, Hernandez Diana, Johnson Christopher J., Rybtsov Stanislav, Ramathas Vidya, Jeyakumar Mylvaganam, Watson Thomas, Hook Lilian, Medvinsky A L., Mason Chris, et al. , PLoS One, 2014, Volume 9, Issue 9, p.e104301, (2014)

Identification of the niche and phenotype of the first human hematopoietic stem cells. Ivanovs, Andrejs, Rybtsov Stanislav, Anderson Richard A., Turner Marc L., and Medvinsky A L. , Stem Cell Reports, 2014 Apr 8, Volume 2, Issue 4, p.449-56, (2014)

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. Liakhovitskaia, Anna, Rybtsov Stanislav, Smith Tom, Batsivari Antoniana, Rybtsova Natalia, Rode Christina, de Bruijn Marella, Buchholz Frank, Gordon-Keylock Sabrina, Zhao Suling, et al. , Development, 2014 Sep, Volume 141, Issue 17, p.3319-23, (2014)

2013

Role of host cell traversal by the malaria sporozoite during liver infection. Tavares, Joana, Formaglio Pauline, Thiberge Sabine, Mordelet Elodie, van Rooijen Nico, Medvinsky A L., Ménard Robert, and Amino Rogerio , J Exp Med, 2013 May 6, Volume 210, Issue 5, p.905-15, (2013)

Imaging sporozoite cell traversal in the liver of mice. Tavares, Joana, Formaglio Pauline, Medvinsky A L., Ménard Robert, and Amino Rogerio , Methods Mol Biol, 2013, Volume 923, p.401-10, (2013)

Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs. Gordon-Keylock, Sabrina, Sobiesiak Malgorzata, Rybtsov Stanislav, Moore Kate, and Medvinsky A L. , Blood, 2013 Oct 3, Volume 122, Issue 14, p.2338-45, (2013)

Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration. Voronov, Dmitry, Gromova Anastasia, Liu Daren, Zoukhri Driss, Medvinsky A L., Meech Robyn, and Makarenkova Helen P. , Invest Ophthalmol Vis Sci, 2013 May, Volume 54, Issue 5, p.3115-25, (2013)

Postmenstrual gestational age should be used with care in studies of early human hematopoietic development. Ivanovs, Andrejs, Rybtsov Stanislav, Anderson Richard A., Turner Marc L., and Medvinsky A L. , Blood, 2013 Apr 11, Volume 121, Issue 15, p.3051-2, (2013)

2012

Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis. Fitch, Simon R., Kimber Gillian M., Wilson Nicola K., Parker Aimée, Mirshekar-Syahkal Bahar, Göttgens Berthold, Medvinsky A L., Dzierzak Elaine, and Ottersbach Katrin , Cell Stem Cell, 2012 Oct 5, Volume 11, Issue 4, p.554-66, (2012)

2011

Endothelio-hematopoietic relationship: getting closer to the beginnings. Gordon-Keylock, Sabrina, and Medvinsky A L. , BMC Biol, 2011, Volume 9, p.88, (2011)

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. Ivanovs, Andrejs, Rybtsov Stanislav, Welch Lindsey, Anderson Richard A., Turner Marc L., and Medvinsky A L. , J Exp Med, 2011 Nov 21, Volume 208, Issue 12, p.2417-27, (2011)

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region. Rybtsov, Stanislav, Sobiesiak Malgorzata, Taoudi Samir, Souilhol Céline, Senserrich Jordi, Liakhovitskaia Anna, Ivanovs Andrejs, Frampton Jon, Zhao Suling, and Medvinsky A L. , J Exp Med, 2011 Jun 6, Volume 208, Issue 6, p.1305-15, (2011)

Embryonic origin of the adult hematopoietic system: advances and questions. Medvinsky, A L., Rybtsov Stanislav, and Taoudi Samir , Development, 2011 Mar, Volume 138, Issue 6, p.1017-31, (2011)

Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis. Hills, David, Gribi Ruby, Ure Jan, Buza-Vidas Natalija, Luc Sidinh, Jacobsen Sten Eirik W., and Medvinsky A L. , Blood, 2011 Mar 31, Volume 117, Issue 13, p.3521-8, (2011)

2010

Developmental hematopoiesis - preface. Durand, Charles, Jaffredo Thierry, and Medvinsky A L. , Int J Dev Biol, 2010, Volume 54, Issue 6-7, p.947-9, (2010)

Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development. Taylor, Erin, Taoudi Samir, and Medvinsky A L. , Int J Dev Biol, 2010, Volume 54, Issue 6-7, p.1055-60, (2010)

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Jakobsson, Lars, Franco Claudio A., Bentley Katie, Collins Russell T., Ponsioen Bas, Aspalter Irene M., Rosewell Ian, Busse Marta, Thurston Gavin, Medvinsky A L., et al. , Nat Cell Biol, 2010 Oct, Volume 12, Issue 10, p.943-53, (2010)

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. Xu, Yunling, Yuan Li, Mak Judy, Pardanaud Luc, Caunt Maresa, Kasman Ian, Larrivée Bruno, Del Toro Raquel, Suchting Steven, Medvinsky A L., et al. , J Cell Biol, 2010 Jan 11, Volume 188, Issue 1, p.115-30, (2010)

The essential requirement for Runx1 in the development of the sternum. Liakhovitskaia, Anna, Lana-Elola Eva, Stamateris Evangelos, Rice David P., Hof Rob J. van 't, and Medvinsky A L. , Dev Biol, 2010 Apr 15, Volume 340, Issue 2, p.539-46, (2010)

2009

Alternative Runx1 promoter usage in mouse developmental hematopoiesis. Bee, Thomas, Liddiard Kate, Swiers Gemma, Bickley Sorrel R. B., Vink Chris S., Jarratt Andrew, Hughes Jim, Medvinsky A L., and de Bruijn Marella F. T. R. , Blood Cells Mol Dis, 2009 Jul-Aug, Volume 43, Issue 1, p.35-42, (2009)

Restoration of Runx1 expression in the Tie2 cell compartment rescues definitive hematopoietic stem cells and extends life of Runx1 knockout animals until birth. Liakhovitskaia, Anna, Gribi Ruby, Stamateris Evangelos, Villain Gaelle, Jaffredo Thierry, Wilkie Ron, Gilchrist Derek, Yang Jian, Ure Janice, and Medvinsky A L. , Stem Cells, 2009 Jul, Volume 27, Issue 7, p.1616-24, (2009)

Regulation of boundary cap neural crest stem cell differentiation after transplantation. Aldskogius, Hakan, Berens Christian, Kanaykina Nadezda, Liakhovitskaia Anna, Medvinsky A L., Sandelin Martin, Schreiner Silke, Wegner Michael, Hjerling-Leffler Jens, and Kozlova Elena N. , Stem Cells, 2009 Jul, Volume 27, Issue 7, p.1592-603, (2009)

A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations. Sheridan, Julie M., Taoudi Samir, Medvinsky A L., and C Blackburn Clare , Genesis, 2009 May, Volume 47, Issue 5, p.346-51, (2009)

2008

The discovery of a source of adult hematopoietic cells in the embryo. Dzierzak, Elaine, and Medvinsky A L. , Development, 2008 Aug, Volume 135, Issue 14, p.2343-6, (2008)

Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+CD45+ pre-definitive HSCs. Taoudi, Samir, le Gonneau Christè, Moore Kate, Sheridan Julie M., C Blackburn Clare, Taylor Erin, and Medvinsky A L. , Cell Stem Cell, 2008 Jul 3, Volume 3, Issue 1, p.99-108, (2008)

Transgenic tools for analysis of the haematopoietic system: knock-in CD45 reporter and deletor mice. Yang, Jian, Hills David, Taylor Erin, Pfeffer Klaus, Ure Jan, and Medvinsky A L. , J Immunol Methods, 2008 Sep 15, Volume 337, Issue 2, p.81-7, (2008)

Analysis and manipulation of hematopoietic progenitor and stem cells from murine embryonic tissues. Medvinsky, A L., Taoudi Samir, Mendes Sandra, and Dzierzak Elaine , Curr Protoc Stem Cell Biol, 2008 Jan, Volume Chapter 2, p.Unit 2A.6, (2008)

Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1. Stifani, Nicolas, Freitas Adriana R. O., Liakhovitskaia Anna, Medvinsky A L., Kania Artur, and Stifani Stefano , Proc Natl Acad Sci U S A, 2008 Apr 29, Volume 105, Issue 17, p.6451-6, (2008)

2007

Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta. Taoudi, Samir, and Medvinsky A L. , Proc Natl Acad Sci U S A, 2007 May 29, Volume 104, Issue 22, p.9399-403, (2007)

2006

Multifunctional reversible knockout/reporter system enabling fully functional reconstitution of the AML1/Runx1 locus and rescue of hematopoiesis. Samokhvalov, Igor M., Thomson Andrew M., Lalancette Claudia, Liakhovitskaia Anna, Ure Janice, and Medvinsky A L. , Genesis, 2006 Mar, Volume 44, Issue 3, p.115-21, (2006)

The differentiation program of embryonic definitive hematopoietic stem cells is largely alpha4 integrin independent. Gribi, Ruby, Hook Lilian, Ure Janice, and Medvinsky A L. , Blood, 2006 Jul 15, Volume 108, Issue 2, p.501-9, (2006)

2005

Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver. Taoudi, Samir, Morrison Aline M., Inoue Hirofumi, Gribi Ruby, Ure Janice, and Medvinsky A L. , Development, 2005 Sep, Volume 132, Issue 18, p.4179-91, (2005)

2003

Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice Gilchrist, Derek S., Ure Jan, Hook Lilian, and Medvinsky A L. , genesis, Jan-07-2003, Volume 36, Issue 3, p.168 - 176, (2003)

Stem cells: Fusion brings down barriers. Medvinsky, A L., and Smith Austin , Nature, 2003 Apr 24, Volume 422, Issue 6934, p.823-5, (2003)

2002

Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity. Oostendorp, Robert A. J., Harvey Kirsty N., Kusadasi Nuray, de Bruijn Marella F. T. R., Saris Chris, Ploemacher Rob E., Medvinsky A L., and Dzierzak Elaine , Blood, 2002 Feb 15, Volume 99, Issue 4, p.1183-9, (2002)

Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis. Oostendorp, Robert A. J., Medvinsky A L., Kusadasi Nuray, Nakayama Naoki, Harvey Kirsty, Orelio Claudia, Ottersbach Katrin, Covey Todd, Ploemacher Rob E., Saris Chris, et al. , J Cell Sci, 2002 May 15, Volume 115, Issue Pt 10, p.2099-108, (2002)

Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver. Kumaravelu, Parasakthy, Hook Lilian, Morrison Aline M., Ure Jan, Zhao Suling, Zuyev Sergei, Ansell John D., and Medvinsky A L. , Development, 2002 Nov, Volume 129, Issue 21, p.4891-9, (2002)

1999

Development of the hematopoietic stem cell: can we describe it? Medvinsky, A L., and Dzierzak Elaine , Blood, 1999 Nov 15, Volume 94, Issue 10, p.3613-4, (1999)

1998

Developmental origins of hematopoietic stem cells in: “Molecular Biology of B and T cell development” Medvinsky, A L., and Dzierzak Elaine , Molecular Biology of B and T cell development, New Jersey, (1998)

Development of the definitive hematopoietic hierarchy in the mouse. Medvinsky, A L., and Dzierzak Elaine , Dev Comp Immunol, 1998 May-Jun, Volume 22, Issue 3, p.289-301, (1998)

Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo. Dzierzak, Elaine, Medvinsky A L., and de Bruijn Marella F. T. R. , Immunol Today, 1998 May, Volume 19, Issue 5, p.228-36, (1998)

1996

Definitive hematopoiesis is autonomously initiated by the AGM region. Medvinsky, A L., and Dzierzak Elaine , Cell, 1996 Sep 20, Volume 86, Issue 6, p.897-906, (1996)

Development of day-8 colony-forming unit-spleen hematopoietic progenitors during early murine embryogenesis: spatial and temporal mapping. Medvinsky, A L., Gan O I., Semenova M L., and Samoylina N L. , Blood, 1996 Jan 15, Volume 87, Issue 2, p.557-66, (1996)

1995

Development of hematopoietic stem cell activity in the mouse embryo Dzierzak, Elaine, Muller A, Sinclair A, Miles C, Gillett N, Daly B, Sanchez M-J, and Medvinsky A L. , Ontogeny of Hematopoiesis Aplastic Anemia, Volume 235, p.13-16, (1995)

Mouse embryonic hematopoiesis. Dzierzak, Elaine, and Medvinsky A L. , Trends Genet, 1995 Sep, Volume 11, Issue 9, p.359-66, (1995)

1994

Development of hematopoietic stem cell activity in the mouse embryo. Müller, A M., Medvinsky A L., Strouboulis J, Grosveld F, and Dzierzak Elaine , Immunity, 1994 Jul, Volume 1, Issue 4, p.291-301, (1994)

1993

Common antigen of oval and biliary epithelial cells (A6) is a differentiation marker of epithelial and erythroid cell lineages in early development of the mouse. Engelhardt, N V., Factor V M., Medvinsky A L., Baranov V N., Lazareva M N., and Poltoranina V S. , Differentiation, 1993 Dec, Volume 55, Issue 1, p.19-26, (1993)

An early pre-liver intraembryonic source of CFU-S in the developing mouse. Medvinsky, A L., Samoylina N L., Müller A M., and Dzierzak Elaine , Nature, 1993 Jul 1, Volume 364, Issue 6432, p.64-7, (1993)

1992

Hemapoietic stem cells in embryogenesis of the mouse in Hematology and Blood Transfusion Samoylina, N L., Medvinsky A L., Gan O I., and Manakova T E. , Modern Trends in Human Leukemia , Volume IX, Berlin, p.106-109, (1992)

1991

Expression of biliary epithelial cell markers during embryogenesis and hepatocarcinogenesis in mice Engelgart, N V., Factor V M., Baranov V N., Medvinsky A L., Poltoranina V S., and Yazova A K. , Ontogenez, Volume 22, Issue 4, p.395-396, (1991)

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