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Blood flow controls bone vascular function and osteogenesis.

TitleBlood flow controls bone vascular function and osteogenesis.
Publication TypeJournal Article
Year of Publication2016
AuthorsRamasamy SK, Kusumbe AP, Schiller M, Zeuschner D, M Bixel G, Milia C, Gamrekelashvili J, Limbourg A, Medvinsky AL, Santoro MM, Limbourg FP, Adams RH
JournalNat Commun
Volume7
Pagination13601
Date Published2016 Dec 06
ISSN2041-1723
Abstract

While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Intravital imaging reveals that vessel growth in murine long bone involves the extension and anastomotic fusion of endothelial buds. Impaired blood flow leads to defective angiogenesis and osteogenesis, and downregulation of Notch signalling in endothelial cells. In aged mice, skeletal blood flow and endothelial Notch activity are also reduced leading to decreased angiogenesis and osteogenesis, which is reverted by genetic reactivation of Notch. Blood flow and angiogenesis in aged mice are also enhanced on administration of bisphosphonate, a class of drugs frequently used for the treatment of osteoporosis. We propose that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system.

DOI10.1038/ncomms13601
Alternate JournalNat Commun
PubMed ID27922003
Publication institute
CRM