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Ontogeny of the Hematopoietic System. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 1–14.

TitleOntogeny of the Hematopoietic System. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 1, pp. 1–14.
Publication TypeBook Chapter
Year of Publication2016
AuthorsCiau-Uitz A, Patient R, Medvinsky AL
Book TitleEncyclopedia of Immunobiology
VolumeVol 1
PublisherOxford Academic Press
CityOxford
Abstract

As for most other tissues and organs, the hematopoietic system is formed during gastrulation and organogenesis. The
mesoderm gives rise to hematovascular progenitors which through cellular intermediates go on to differentiate into blood.
The hematopoietic system develops in waves: in all vertebrate species, early transitory embryonic waves are gradually replaced
by a permanent adult hierarchy which persists throughout the animal’s lifespan. During development, hematopoietic stem
cells (HSCs) undergo stepwise differentiation changing their phenotype, functional properties, and locations. Complex cell
movements, molecular signaling, and interplay of transcription factors underlie these processes. This article focuses on tissue
origin and mechanisms underpinning the development of the adult hematopoietic system in light of analysis of different
vertebrate models.

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