Leading science, pioneering therapies
CRM Publications

Embryonic origin of the adult hematopoietic system: advances and questions.

TitleEmbryonic origin of the adult hematopoietic system: advances and questions.
Publication TypeJournal Article
Year of Publication2011
AuthorsMedvinsky AL, Rybtsov S, Taoudi S
Date Published2011 Mar
KeywordsAdult, Animals, Embryo Research, Embryo, Mammalian, Embryonic Development, Hematopoiesis, Hematopoietic Stem Cells, Hematopoietic System, Humans, Models, Biological

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.

Alternate JournalDevelopment
PubMed ID21343360
Grant ListG0900962 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
/ / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom