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Endothelio-hematopoietic relationship: getting closer to the beginnings.

TitleEndothelio-hematopoietic relationship: getting closer to the beginnings.
Publication TypeJournal Article
Year of Publication2011
AuthorsGordon-Keylock S, Medvinsky A
JournalBMC Biol
Volume9
Pagination88
Date Published2011
ISSN1741-7007
KeywordsAnimals, Cell Differentiation, Chick Embryo, Electroporation, Endothelial Cells, Hematopoiesis, Hematopoietic Stem Cells
Abstract

The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in vitro differentiation studies. Teixeira and colleagues describe a novel enhancer that drives specific eGFP expression in blood islands of the electroporated chick embryo, thereby presenting a tool potentially suitable for analysis of hemangioblast differentiation and development of blood islands.

DOI10.1186/1741-7007-9-88
Alternate JournalBMC Biol.
PubMed ID22204560
PubMed Central IDPMC3247189
Grant ListG0900962 / / Medical Research Council / United Kingdom