Tilo Kunath

Position:

Reader in Regenerative Neurobiology

Telephone:

0131 651 9500

Display email:

tilo.kunath@ed.ac.uk

Biography:

PhD at the University of Toronto with Prof Janet Rossant
Post-doctoral studies with Prof Austin Smith, Edinburgh
Visiting professor at the University of Tsukuba

Publications

2017

A synthetic cell permeable antioxidant protects neurons against acute oxidative stress Drummond, Nicola, Davies Nick O., Lovett Janet E., Miller Mark R., Cook Graeme, Becker Thomas, Becker Catherina G., McPhail Donald B., and Kunath Tilo , Scientific Reports, Jan-12-2017, Issue 1Suppl, (2017)

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Imamura, Keiko, Izumi Yuishin, Watanabe Akira, Tsukita Kayoko, Woltjen Knut, Yamamoto Takuya, Hotta Akitsu, Kondo Takayuki, Kitaoka Shiho, Ohta Akira, et al. , Sci Transl Med, 2017 May 24, Volume 9, Issue 391, (2017)

Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines. Natalwala, Ammar, and Kunath Tilo , Prog Brain Res, 2017, Volume 230, p.133-150, (2017)

Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations. Dolt, Karamjit Singh, Hammachi Fella, and Kunath Tilo , Brain Pathol, 2017 Jul, Volume 27, Issue 4, p.545-551, (2017)

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology. Amorim, Inês S., Graham Laura C., Carter Roderick N., Morton Nicholas M., Hammachi Fella, Kunath Tilo, Pennetta Giuseppa, Carpanini Sarah M., Manson Jean C., Lamont Douglas J., et al. , J Cell Sci, 2017 Jan 15, Volume 130, Issue 2, p.325-331, (2017)

2016

Derivation of the clinical grade human embryonic stem cell line RCe021-A (RC-17). de Sousa, P A., Tye B J., Bruce K, Dand P, Russell G, Collins D M., Greenshields A, McDonald K, Bradburn H, Allan D, et al. , Stem Cell Res, 2016 Apr 30, Volume 17, Issue 1, p.1-5, (2016)

Derivation of the clinical grade human embryonic stem cell line RCe013-A (RC-9). de Sousa, P A., Tye B J., Bruce K, Dand P, Russell G, Collins D M., Greenshields A, McDonald K, Bradburn H, Canham M A., et al. , Stem Cell Res, 2016 May 06, Volume 17, Issue 1, p.36-41, (2016)

Derivation of the clinical grade human embryonic stem cell line RCe015-A (RC-11). de Sousa, P A., Tye B J., Bruce K, Dand P, Russell G, Collins D M., Greenshields A, McDonald K, Bradburn H, Laurie A, et al. , Stem Cell Res, 2016 May 07, Volume 17, Issue 1, p.42-48, (2016)

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells. Sotthibundhu, Areechun, McDonagh Katya, von Kriegsheim Alexander, Garcia-Munoz Amaya, Klawiter Agnieszka, Thompson Kerry, Chauhan Kapil Dev, Krawczyk Janusz, McInerney Veronica, Dockery Peter, et al. , Stem Cell Res Ther, 2016 Nov 15, Volume 7, Issue 1, p.166, (2016)

2015

The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines. Canham, Maurice A., Van Deusen Amy, Brison Daniel R., De Sousa Paul A., Downie Janet, Devito Liani, Hewitt Zoë A., Ilic Dusko, Kimber Susan J., Moore Harry D., et al. , Sci Rep, 2015 Nov 26, Volume 5, p.17258, (2015)

Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors. Holmqvist, Staffan, Brouwer Marinka, Djelloul Mehdi, Diaz Alejandro Garcia, Devine Michael J., Hammarberg Anna, Fog Karina, Kunath Tilo, and Roybon Laurent , Stem Cell Res, 2015 Jul, Volume 15, Issue 1, p.203-20, (2015)

Conformational dynamics of α-synuclein: insights from mass spectrometry Phillips, Ashley S., Gomes Alexandre F., Kalapothakis Jason M. D., Gillam Jay E., Gasparavicius Jonas, Gozzo Fabio C., Kunath Tilo, MacPhee Cait, and Barran Perdita E. , The Analyst, Jan-01-2015, Volume 140, Issue 9, p.3070 - 3081, (2015)

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT Sposito, Teresa, Preza Elisavet, Mahoney Colin J., Salvia úria ó-, Ryan Natalie S., Morris Huw R., Arber Charles, Devine Michael J., Houlden Henry, Warner Thomas T., et al. , Human Molecular Genetics, Mar-09-2016, Volume 24, Issue 18, p.5260 - 5269, (2015)

Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors Holmqvist, Staffan, Brouwer Marinka, Djelloul Mehdi, Diaz Alejandro Garcia, Devine Michael J., Hammarberg Anna, Fog Karina, Kunath Tilo, and Roybon Laurent , Stem Cell Research, Jan-07-2015, Volume 15, Issue 1, p.203 - 220, (2015)

The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines Canham, Maurice A., Van Deusen Amy, Brison Daniel R., De Sousa Paul A., Downie Janet, Devito Liani, Hewitt Zoe A., Ilic Dusko, Kimber Susan J., Moore Harry D., et al. , Scientific Reports, Feb-11-2017, Volume 5, p.17258, (2015)

2014

Developmental differences in the expression of FGF receptors between human and mouse embryos. Kunath, Tilo, Yamanaka Y, Detmar J, MacPhee D, Caniggia I, Rossant J, and Jurisicova A , Placenta, 2014 Dec, Volume 35, Issue 12, p.1079-88, (2014)

Developmental differences in the expression of FGF receptors between human and mouse embryos Kunath, Tilo, Yamanaka Y., Detmar J., MacPhee D., Caniggia I., Rossant J., and Jurisicova A. , Placenta, Jan-09-2014, (2014)

2013

ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment. Hamilton, William B., Kaji Keisuke, and Kunath Tilo , PLoS One, 2013, Volume 8, Issue 4, p.e60907, (2013)

2012

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. Paca, Agnieszka, Séguin Cheryle A., Clements Melanie, Ryczko Michael, Rossant Janet, Rodriguez Tristan A., and Kunath Tilo , Dev Biol, 2012 Jan 1, Volume 361, Issue 1, p.90-102, (2012)

2011

Induced pluripotent stem cell technology and stem cell therapy for diabetes. Drummond, Robert J., Kunath Tilo, Mee P J., and Ross James A. , Exp Ther Med, 2011 1, Volume 2, Issue 1, p.3-7, (2011)

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Devine, Michael J., Ryten Mina, Vodicka Petr, Thomson Alison J., Burdon Tom, Houlden Henry, Cavaleri Fatima, Nagano Masumi, Drummond Nicola, Taanman Jan-Willem, et al. , Nat Commun, 2011, Volume 2, p.440, (2011)

Primed for pluripotency. Kunath, Tilo , Cell Stem Cell, 2011 Mar 4, Volume 8, Issue 3, p.241-2, (2011)

2008

Transgenic RNA interference to investigate gene function in the mouse. Kunath, Tilo , Methods Mol Biol, 2008, Volume 461, p.165-86, (2008)

Isolation and manipulation of mouse trophoblast stem cells. Himeno, Emi, Tanaka Satoshi, and Kunath Tilo , Curr Protoc Stem Cell Biol, 2008 Oct, Volume Chapter 1, p.Unit 1E.4, (2008)

2007

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Kunath, Tilo, Saba-El-Leil Marc K., Almousailleakh Marwa, Wray Jason, Meloche Sylvain, and Smith Austin , Development, 2007 Aug, Volume 134, Issue 16, p.2895-902, (2007)

2006

Mouse trophoblast stem cells. Quinn, Jennifer, Kunath Tilo, and Rossant Janet , Methods Mol Med, 2006, Volume 121, p.125-48, (2006)

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Gladdy, Rebecca A., Nutter Lauryl M. J., Kunath Tilo, Danska Jayne S., and Guidos Cynthia J. , Mol Cancer Res, 2006 May, Volume 4, Issue 5, p.311-8, (2006)

2005

Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Kunath, Tilo, Arnaud Danielle, Uy Gary D., Okamoto Ikuhiro, Chureau Corinne, Yamanaka Yojiro, Heard Edith, Gardner Richard L., Avner Philip, and Rossant Janet , Development, 2005 Apr, Volume 132, Issue 7, p.1649-61, (2005)

Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression. Ramos-Mejía, Verónica, Escalante-Alcalde Diana, Kunath Tilo, Ramírez Laura, Gertsenstein Marina, Nagy Andras, and Lomelí Hilda , Dev Dyn, 2005 Jan, Volume 232, Issue 1, p.180-90, (2005)

2004

Early trophoblast determination and stem cell maintenance in the mouse--a review. Kunath, Tilo, Strumpf D, and Rossant J , Placenta, 2004 Apr, Volume 25 Suppl A, p.S32-8, (2004)

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