0131 651 9500 (Reception)
- 2019 – present. Group Leader. MRC Centre for Regenerative Medicine, University of Edinburgh.
- 2018–2019. Simons Initiative for the Developing Brain (SIDB) Transition to independence post. The University of Edinburgh.
- 2010–2018. Postdoc with Prof. Wendy Bickmore. MRC Human Genetics Unit. Epigenetics of mammalian embryonic development.
- 2008-2010. Postdoc with Sir Adrian Bird. Wellcome Trust Centre for Cell Biology, The University of Edinburgh. DNA methylation screening in primary Human brain tissue.
- 2004-2008. PhD student with Sir Adrian Bird. Wellcome Trust Centre for Cell Biology, The University of Edinburgh. Developing novel biochemical approaches for the characterisation of mammalian CpG island methylation.
- 1999-2003. BSc in Molecular Biology. The University of Edinburgh.
Chromatin folding and nuclear architecture: PRC1 function in 3D. Illingworth, Robert , Curr Opin Genet Dev, 2019 Jul 16, Volume 55, p.82-90, (2019)
DNA methylation directs polycomb-dependent 3D genome re- organisation in naive pluripotency McLaughlin, KA, Flyamer IM, Thomson JP, Mjoseng HK, Shukla R, Williamson I, Grimes GR, Illingworth Robert, Adams IR, and Pennings S , (2019)
Coolpup.py – a versatile tool to perform pile-up analysis of Hi-C data Flyamer, IM, Illingworth Robert, and Bickmore WA , (2019)
PARP mediated chromatin unfolding is coupled to long-range enhancer activation NS, Benabdallah, I Williamson, Illingworth Robert, S Boyle, GR Grimes, P Therizols, and WA Bickmore , (2017)
Polycomb-mediated chromatin compaction weathers the STORM Williamson, I, Bickmore WA, and Illingworth Robert , Genome biology 2016, (2016)
Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer. Thomson, John P., Ottaviano Raffaele, Unterberger Elif B., Lempiäinen Harri, Muller Arne, Terranova Remi, Illingworth Robert, Webb Shaun, Kerr Alastair R. W., Lyall Marcus J., et al. , Cancer Res, 2016 05 15, Volume 76, Issue 10, p.3097-108, (2016)
Polycomb enables primitive endoderm lineage priming in embryonic stem cells. Illingworth, Robert, Hölzenspies Jurriaan J., Roske Fabian V., Bickmore Wendy A., and Brickman Joshua M. , Elife, 2016 10 10, Volume 5, (2016)
The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development. Illingworth, Robert, Moffat Michael, Mann Abigail R., Read David, Hunter Chris J., Pradeepa Madapura M., Adams Ian R., and Bickmore Wendy A. , Genes Dev, 2015 Sep 15, Volume 29, Issue 18, p.1897-902, (2015)
Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome. Illingworth, Robert, Gruenewald-Schneider Ulrike, De Sousa Dina, Webb Shaun, Merusi Cara, Kerr Alastair R. W., James Keith D., Smith Colin, Walker Robert, Andrews Robert, et al. , Nucleic Acids Res, 2015 Jan, Volume 43, Issue 2, p.732-44, (2015)
Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization. Williamson, Iain, Berlivet Soizik, Eskeland Ragnhild, Boyle Shelagh, Illingworth Robert, Paquette Denis, Dostie Josée, and Bickmore Wendy A. , Genes Dev, 2014 Dec 15, Volume 28, Issue 24, p.2778-91, (2014)
Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells. Therizols, Pierre, Illingworth Robert, Courilleau Celine, Boyle Shelagh, Wood Andrew J., and Bickmore Wendy A. , Science, 2014 Dec 05, Volume 346, Issue 6214, p.1238-42, (2014)
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. Illingworth, Robert, Botting Catherine H., Grimes Graeme R., Bickmore Wendy A., and Eskeland Ragnhild , PLoS One, 2012, Volume 7, Issue 4, p.e34848, (2012)
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Clouaire, Thomas, Webb Shaun, Skene Pete, Illingworth Robert, Kerr Alastair, Andrews Robert, Lee Jeong-Heon, Skalnik David, and Bird Adrian , Genes Dev, 2012 Aug 01, Volume 26, Issue 15, p.1714-28, (2012)
Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Deaton, Aimée M., Webb Shaun, Kerr Alastair R. W., Illingworth Robert, Guy Jacky, Andrews Robert, and Bird Adrian , Genome Res, 2011 Jul, Volume 21, Issue 7, p.1074-86, (2011)
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Thomson, John P., Skene Peter J., Selfridge Jim, Clouaire Thomas, Guy Jacky, Webb Shaun, Kerr Alastair R. W., Deaton Aimée, Andrews Rob, James Keith D., et al. , Nature, 2010 Apr 15, Volume 464, Issue 7291, p.1082-6, (2010)
Immunostaining of modified histones defines high-level features of the human metaphase epigenome. Terrenoire, Edith, McRonald Fiona, Halsall John A., Page Paula, Illingworth Robert, A Taylor Malcolm R., Davison Val, O'Neill Laura P., and Turner Bryan M. , Genome Biol, 2010, Volume 11, Issue 11, p.R110, (2010)
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Skene, Peter J., Illingworth Robert, Webb Shaun, Kerr Alastair R. W., James Keith D., Turner Daniel J., Andrews Rob, and Bird Adrian P. , Mol Cell, 2010 Feb 26, Volume 37, Issue 4, p.457-68, (2010)
Orphan CpG islands identify numerous conserved promoters in the mammalian genome. Illingworth, Robert, Gruenewald-Schneider Ulrike, Webb Shaun, Kerr Alastair R. W., James Keith D., Turner Daniel J., Smith Colin, Harrison David J., Andrews Robert, and Bird Adrian P. , PLoS Genet, 2010 Sep 23, Volume 6, Issue 9, p.e1001134, (2010)
CpG islands--'a rough guide'. Illingworth, Robert, and Bird Adrian P. , FEBS Lett, 2009 Jun 05, Volume 583, Issue 11, p.1713-20, (2009)
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. Illingworth, Robert, Kerr Alastair, Desousa Dina, Jørgensen Helle, Ellis Peter, Stalker Jim, Jackson David, Clee Chris, Plumb Robert, Rogers Jane, et al. , PLoS Biol, 2008 Jan, Volume 6, Issue 1, p.e22, (2008)