Nick Mullin

nmullin@staffmail.ed.ac.uk

Biography:

Study the biochemistry of transcription factors involved in regulation of pluripotency.

Publications

2017

Distinct SoxB1 networks are required for naïve and primed pluripotency. Corsinotti, Andrea, Wong Frederick Ck, Tatar Tülin, Szczerbinska Iwona, Halbritter Florian, Colby Douglas, Gogolok Sabine, Pantier Raphaël, Liggat Kirsten, Mirfazeli Elham S., et al. , Elife, 2017 12 19, Volume 6, (2017)

A new twist to Sin3 complexes in pluripotent cells. Pantier, Raphaël, Mullin Nicholas P., and Chambers Ian , EMBO J, 2017 Jun 28, (2017)

2016

Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function. Mullin, Nicholas P., Gagliardi Alessia, Khoa Le Tran Phuc, Colby Douglas, Hall-Ponsele Elisa, Rowe Arthur J., and Chambers Ian , J Mol Biol, 2017 May 19, (2016)

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells. Novo, Clara Lopes, Tang Calvin, Ahmed Kashif, Djuric Ugljesa, Fussner Eden, Mullin Nicholas P., Morgan Natasha P., Hayre Jasvinder, Sienerth Arnold R., Elderkin Sarah, et al. , Genes Dev, 2016 May 1, Volume 30, Issue 9, p.1101-15, (2016)

2013

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi, Alessia, Mullin Nicholas P., Tan Zi Ying, Colby Douglas, Kousa Anastasia I., Halbritter Florian, Weiss Jason T., Felker Anastasia, Bezstarosti Karel, Favaro Rebecca, et al. , EMBO J, 2013 Aug 14, Volume 32, Issue 16, p.2231-47, (2013)

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Karwacki-Neisius, Violetta, Göke Jonathan, Osorno Rodrigo, Halbritter Florian, Ng Jia Hui, Weiße Andrea Y., Wong Frederick, Gagliardi Alessia, Mullin Nicholas P., Festuccia Nicola, et al. , Cell Stem Cell, 2013 May 2, Volume 12, Issue 5, p.531-45, (2013)

2012

OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. Navarro, Pablo, Festuccia Nicola, Colby Douglas, Gagliardi Alessia, Mullin Nicholas P., Zhang Wensheng, Karwacki-Neisius Violetta, Osorno Rodrigo, Kelly David, Robertson Morag, et al. , EMBO J, 2012 Dec 12, Volume 31, Issue 24, p.4547-62, (2012)

2011

The Function of Nanog in Pluripotency Mullin, Nicholas P., and Chambers Ian , Nuclear Reprogramming and Stem Cells, (2011)

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells. Navarro, Pablo, Moffat Michael, Mullin Nicholas P., and Chambers Ian , Hum Genet, 2011 Aug, Volume 130, Issue 2, p.255-64, (2011)

2010

An Oct4-centered protein interaction network in embryonic stem cells. van den Berg, Debbie L. C., Snoek Tim, Mullin Nicholas P., Yates Adam, Bezstarosti Karel, Demmers Jeroen, Chambers Ian, and Poot Raymond A. , Cell Stem Cell, 2010 Apr 2, Volume 6, Issue 4, p.369-81, (2010)

2008

The pluripotency rheostat Nanog functions as a dimer. Mullin, Nicholas P., Yates Adam, Rowe Arthur J., Nijmeijer Bianca, Colby Douglas, Barlow Paul N., Walkinshaw Malcolm D., and Chambers Ian , Biochem J, 2008 Apr 15, Volume 411, Issue 2, p.227-31, (2008)

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