/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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						<ul class="links inline"><li  class="first menu-251 depth-1"><div class="menu-item-wrapper"><a href="/">Home</a></div></li><li  class="has-children menu-2052 depth-1" title="What are stem cells? Learn about their abilities and how they build and repair the body. Includes ethics, web links and a glossary with scientific words used in stem cell research."><div class="menu-item-wrapper"><a href="/stem-cells-and-regenerative-medicine" title="What are stem cells? Learn about their abilities and how they build and repair the body. Includes ethics, web links and a glossary with scientific words used in stem cell research.">About stem cells</a><ul><li  class="first has-children menu-1957 depth-2" title="More about diseases researchers and clinicians at the MRC Centre for Regenerative Medicine (CRM), University of Edinburgh, study. Diseases include brain cancer, diabetes, leukaemia, liver disease, motor neurone disease, multiple sclerosis and parkinson’s disease."><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study" title="More about diseases researchers and clinicians at the MRC Centre for Regenerative Medicine (CRM), University of Edinburgh, study. Diseases include brain cancer, diabetes, leukaemia, liver disease, motor neurone disease, multiple sclerosis and parkinson’s disease.">Diseases we study</a><ul><li  class="first menu-2321 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/information-patients">Information for patients</a></div></li><li  class="menu-2538 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/brain-cancer">Brain cancer</a></div></li><li  class="menu-3570 depth-3" title="Macrophage cell therapy for liver cirrhosis"><div class="menu-item-wrapper"><a href="/macrophage-cell-therapy-liver-cirrhosis" title="Macrophage cell therapy for liver cirrhosis">Cell Therapy Trials</a></div></li><li  class="menu-3279 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/heart-disease">Heart disease</a></div></li><li  class="menu-2540 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/leukaemia">Leukaemia</a></div></li><li  class="menu-2541 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/liver-disease-and-cancer">Liver disease and cancer</a></div></li><li  class="menu-2542 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/motor-neurone-disease">Motor neurone disease</a></div></li><li  class="menu-2537 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/multiple-sclerosis">Multiple sclerosis</a></div></li><li  class="last menu-2543 depth-3"><div class="menu-item-wrapper"><a href="/about-stem-cells/diseases-we-study/parkinsons-disease">Parkinson&#039;s disease</a></div></li></ul></div></li><li  class="menu-2056 depth-2" title="What are stem cells? Find out more about stem cells, their abilities and how they build and repair the body."><div class="menu-item-wrapper"><a href="/about-stem-cells/what-are-stem-cells" title="What are stem cells? Find out more about stem cells, their abilities and how they build and repair the body.">What are stem cells?</a></div></li><li  class="menu-2271 depth-2" title="Ethics: learn about some of the ethical issues surrounding stem cell research and regenerative medicine."><div class="menu-item-wrapper"><a href="/about-stem-cells/ethics" title="Ethics: learn about some of the ethical issues surrounding stem cell research and regenerative medicine.">Ethics</a></div></li><li  class="menu-2270 depth-2"><div class="menu-item-wrapper"><a href="/about-stem-cells/history">History</a></div></li><li  class="menu-2272 depth-2" title="Web links: useful information on stem cells and regenerative medicine."><div class="menu-item-wrapper"><a href="/about-stem-cells/web-links" title="Web links: useful information on stem cells and regenerative medicine.">Web links</a></div></li><li  class="menu-2273 depth-2" title="Glossary: look up definitions of scientific words often used in stem cell research and 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      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-10-27T00:00:00+01:00"><span class="month">Oct</span> <span class="day">27</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Congratulations to CRM PhD student Sophie Quick for winning one of three runner up prizes in this year’s MRC Max Perutz Science Writing competition.</p>

      </div>
  

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      <a href="/news/crm-student-sophie-quick-wins-prize-mrc-max-perutz-science-writing-competition">Read more &raquo;</a>
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      <a href="/news/building-future-regenerative-medicine-edinburgh">Building for the future of Regenerative Medicine in Edinburgh</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-10-23T00:00:00+01:00"><span class="month">Oct</span> <span class="day">23</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>The CRM is marking the beginning of construction of the Centre of Tissue Repair. Together with the Centre of Regenerative Medicine, they will form the Institute for Regeneration and Repair.</p>

      </div>
  

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      <a href="/news/cell-based-therapies-could-be-boosted-new-antioxidant">Cell-based therapies could be boosted by new antioxidant</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-09-20T00:00:00+01:00"><span class="month">Sep</span> <span class="day">20</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Cell therapies being developed to treat a range of conditions could be improved by a chemical compound that aids their survival, new CRM research suggests.</p>

      </div>
  

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      <a href="/news/cell-based-therapies-could-be-boosted-new-antioxidant">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/blindness-study-shows-how-gene-causes-middle-age-sight-loss">Blindness study shows how gene causes middle-age sight loss</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-09-05T00:00:00+01:00"><span class="month">Sep</span> <span class="day">5</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p><span style="mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman';">Chemical changes in the eye that can lead to blindness have been identified by a team led by former CRM researcher Dr Roly Megaw.<span style="mso-spacerun: yes;"> <br /></span></span></p>

      </div>
  

      <div>
  
    
      <a href="/news/blindness-study-shows-how-gene-causes-middle-age-sight-loss">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/new-%E2%80%9Cbackup%E2%80%9D-liver-repair-mechanism">New “backup” liver repair mechanism</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-07-12T00:00:00+01:00"><span class="month">Jul</span> <span class="day">12</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>New study reveals cells can be reprogrammed to repair severe liver injury.</p>

      </div>
  

      <div>
  
    
      <a href="/news/new-%E2%80%9Cbackup%E2%80%9D-liver-repair-mechanism">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/art-exhibition-crm-scientists">An art exhibition, by CRM scientists</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-06-09T00:00:00+01:00"><span class="month">Jun</span> <span class="day">9</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>The MRC Centre for Regenerative Medicine will be a hosting a pop-up art exhibit on 22 June. <em>Regeneration: A story of becoming</em>, will feature original artworks created by scientists from the centre. The exhibition is a part of the Medical Research Council’s annual Festival of Medical Research.</p>

      </div>
  

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      <a href="/news/art-exhibition-crm-scientists">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/cigarette-damage-unborn-children-revealed-stem-cell-study">Cigarette damage to unborn children revealed in stem cell study</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-05-30T00:00:00+01:00"><span class="month">May</span> <span class="day">30</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Chemicals found in cigarette smoke have been shown to damage foetal liver cells.</p>

      </div>
  

      <div>
  
    
      <a href="/news/cigarette-damage-unborn-children-revealed-stem-cell-study">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/stem-cell-derived-macrophages-could-treat-liver-fibrosis">Stem cell-derived macrophages could treat liver fibrosis</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-05-24T00:00:00+01:00"><span class="month">May</span> <span class="day">24</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Macrophages derived from embryonic stem cells in the laboratory reduce tissue damage in a mouse model of chronic liver disease. </p>

      </div>
  

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      <a href="/news/stem-cell-derived-macrophages-could-treat-liver-fibrosis">Read more &raquo;</a>
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      <a href="/news/brain-tumours-exploit-proteins-control-normal-brain-stem-cells">Brain tumours exploit proteins that control normal brain stem cells</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-05-12T00:00:00+01:00"><span class="month">May</span> <span class="day">12</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>CRM researchers have pinpointed two key molecules that drive the growth of an aggressive type of adult brain cancer.</p>

      </div>
  

      <div>
  
    
      <a href="/news/brain-tumours-exploit-proteins-control-normal-brain-stem-cells">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/charles-ffrench-constant-elected-fellow-academy-medical-sciences">Charles ffrench-Constant elected Fellow of the Academy of Medical Sciences</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-05-10T00:00:00+01:00"><span class="month">May</span> <span class="day">10</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Former CRM Director and Principal Investigator, Professor Charles ffrench-Constant has been elected to the prestigious Fellowship of the Academy of Medical Sciences. </p>

      </div>
  

      <div>
  
    
      <a href="/news/charles-ffrench-constant-elected-fellow-academy-medical-sciences">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/new-mechanism-repair-testes-offers-hope-fertility">New Mechanism of Repair in the Testes Offers Hope for Fertility</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-05-04T00:00:00+01:00"><span class="month">May</span> <span class="day">4</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>CRM scientists have discovered a tiny group of cells that is critical to repairing damage to the testes.</p>

      </div>
  

      <div>
  
    
      <a href="/news/new-mechanism-repair-testes-offers-hope-fertility">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/%C2%A309m-commercial-collaboration-improve-blood-cell-production-stem-cells">£0.9m Commercial collaboration to improve blood cell production from stem cells</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-04-27T00:00:00+01:00"><span class="month">Apr</span> <span class="day">27</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>CRM scientists have joined forces with Plasticell to secure £920,000 Biomedical Catalyst funding from Innovate UK.  </p>

      </div>
  

      <div>
  
    
      <a href="/news/%C2%A309m-commercial-collaboration-improve-blood-cell-production-stem-cells">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/new-collaboration-accelerate-drug-discovery-using-stem-cell-technology">New Collaboration to Accelerate Drug Discovery Using Stem Cell Technology</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-03-06T00:00:00+00:00"><span class="month">Mar</span> <span class="day">6</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>The MRC-Centre for Regenerative Medicine (MRC-CRM) and the University of Dundee have announced a new collaboration to encourage partnership with the pharmaceutical industry. </p>

      </div>
  

      <div>
  
    
      <a href="/news/new-collaboration-accelerate-drug-discovery-using-stem-cell-technology">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/blood-study-provides-hope-stem-cell-therapy">Blood study provides hope for stem cell therapy</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-02-15T00:00:00+00:00"><span class="month">Feb</span> <span class="day">15</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>CRM researchers have pinpointed a key enzyme that is vital for the production of all blood cells in the body.</p>

      </div>
  

      <div>
  
    
      <a href="/news/blood-study-provides-hope-stem-cell-therapy">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/new-opportunities-screening-models-brain-cancer">New opportunities for screening models in brain cancer</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2017-02-14T00:00:00+00:00"><span class="month">Feb</span> <span class="day">14</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>CRM scientists have been able to make precise genetic changes to mouse and human neuronal stem cells for the first time.  This opens up the possibility for the study of the genetic changes seen in glioblastoma, the most common form of brain cancer.</p>

      </div>
  

      <div>
  
    
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      <h2>
  
    
      <a href="/news/new-clues-cause-bile-duct-cancer">New clues to cause of bile duct cancer</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2016-10-11T00:00:00+01:00"><span class="month">Oct</span> <span class="day">11</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Scientists at the CRM have identified a molecule that drives the development of bile duct cancer.  The research in mice and human cells sheds new light on what triggers the disease and how the illness progresses.</p>

      </div>
  

      <div>
  
    
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      <a href="/news/new-insights-blood-cancer-develops-birth">New insights into blood cancer that develops before birth</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2016-07-07T00:00:00+01:00"><span class="month">Jul</span> <span class="day">7</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Researchers from the Medical Research Council (MRC) Centre for Regenerative Medicine at the <a href="https://www.ed.ac.uk/">University of Edinburgh</a> have identified the cells responsible for a form of leukaemia that can develop while a baby is in the womb. </p>

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      <a href="/news/edinburgh-scientists-get-%C2%A337million-cruk-funding-cutting-edge-cancer-research">Edinburgh scientists to get £3.7million CRUK funding for cutting edge cancer research</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2016-05-13T00:00:00+01:00"><span class="month">May</span> <span class="day">13</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Edinburgh scientists are set to receive a major cash boost from Cancer Research UK which could help to develop groundbreaking new brain tumour treatments.</p>

      </div>
  

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      <a href="/news/edinburgh-scientists-get-%C2%A337million-cruk-funding-cutting-edge-cancer-research">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/%C2%A318m-novel-synthetic-factors-improve-ips-technology">£1.8M for novel synthetic factors to improve iPS technology</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2016-05-06T00:00:00+01:00"><span class="month">May</span> <span class="day">6</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>Dr Abdenour Soufi, a Chancellor’s fellow and junior group leader at the MRC Centre for Regenerative Medicine (CRM), received a prestigious <a href="http://www.mrc.ac.uk%20">Medical Research Council</a> (MRC) Career Development Award (CDA) earlier today.</p>

      </div>
  

      <div>
  
    
      <a href="/news/%C2%A318m-novel-synthetic-factors-improve-ips-technology">Read more &raquo;</a>
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      <h2>
  
    
      <a href="/news/using-cellular-components-treat-drug-overdose">Using cellular components to treat drug overdose</a>
      </h2>
  

      <div>
  
    
      <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2016-04-07T00:00:00+01:00"><span class="month">Apr</span> <span class="day">7</span> <span class="month"></span> <span class="day"></span></span>
      </div>
  

      <div>
  
    
      <p>It may be possible to treat paracetamol overdose in the future using microRNAs to silence transcription of genes that lead to the production of toxic metabolites. This is according to a proof-of-concept study carried out using stem cell models by researchers at the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh.</p>

      </div>
  

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      <a href="/news/using-cellular-components-treat-drug-overdose">Read more &raquo;</a>
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