Leading science, pioneering therapies

Liver stem cells and regeneration group publications

2020

Michailidis E, Vercauteren K, Mancio-Silva L, Andrus L, Jahan C, Ricardo-Lax I, Zou C, Kabbani M, Park P, Quirk C et al..  2020.  Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.Proc Natl Acad Sci U S A. 117(3):1678-1688.

2019

Moroni F, Dwyer BJ, Graham C, Pass C, Bailey L, Ritchie L, Mitchell D, Glover A, Laurie A, Doig S et al..  2019.  Safety profile of autologous macrophage therapy for liver cirrhosisNature Medicine. 257044621231155418109178110191755187195336451016611481593101153050316429215(10):1560-1565.
Carotenuto P, Hedayat S, Fassan M, Cardinale V, Lampis A, Guzzardo V, Vicentini C, Scarpa A, Cascione L, Costantini D et al..  2019.  Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells.Hepatology.
Carpino G, Nevi L, Overi D, Cardinale V, Lu W-Y, Di Matteo S, Safarikia S, Berloco PBartolomeo, Venere R, Onori P et al..  2019.  Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis.Hepatology.
Aloia L, McKie MAlexander, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Cigliano RAiese et al..  2019.  Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.Nat Cell Biol. 21(11):1321-1333.

2018

Russell JO, Lu W-Y, Okabe H, Abrams M, Oertel M, Poddar M, Singh S, Forbes SJ, Monga SP.  2018.  Hepatocyte-specific β-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes.Hepatology.
Rashidi H, Luu N-T, Alwahsh SM, Ginai M, Alhaque S, Dong H, Tomaz RA, Vernay B, Vigneswara V, Hallett JM et al..  2018.  3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.Arch Toxicol. 92(10):3117-3129.
Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu W-Y, Jamieson T, Govaere O, Campbell AD et al..  2018.  TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.Sci Transl Med. 10(454)
Campana L, Lewis PJStarkey, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-González S, Livingstone E, Greenhalgh SN et al..  2018.  The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.J Immunol. 200(3):1169-1187.
Ferreira-González S, Lu W-Y, Raven A, Dwyer B, Man TYung, O'Duibhir E, Lewis PJStarkey, Campana L, Kendall TJ, Bird TG et al..  2018.  Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.Nat Commun. 9(1):1020.

2017

Haideri SS, McKinnon AC, A Taylor H, Kirkwood P, Lewis PJStarkey, O'Duibhir E, Vernay B, Forbes SJ, Forrester LM.  2017.  Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury.NPJ Regen Med. 2:14.
Fraser AR, Pass C, Burgoyne P, Atkinson A, Bailey L, Laurie A, McGowan NWA, Hamid A, Moore JK, Dwyer BJ et al..  2017.  Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis.Cytotherapy.
Raven A, Lu W-Y, Man TYung, Ferreira-González S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V et al..  2017.  Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.Nature.
Haideri SS, McKinnon AC, A. Taylor H, Kirkwood P, Lewis PJStarkey, O'Duibhir E, Vernay B, Forbes SJ, Forrester LM.  2017.  Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injurynpj Regenerative Medicine. 2201345340533010911011514617385458833621119117633130(1)
Moore JK, Mackinnon AC, Man TY, Manning JR, Forbes SJ, Simpson KJ.  2017.  Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.Aliment Pharmacol Ther. 45(3):443-454.
Sharkey J, Lewis PJStarkey, Barrow M, Alwahsh SM, Noble J, Livingstone E, Lennen RJ, Jansen MA, Carrion JGarcia, Liptrott N et al..  2017.  Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.Cytotherapy.

2016

Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Heiden MGVander, Javle M et al..  2016.  Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.J Gastrointest Oncol. 7(6):819-827.
Forbes SJ, Newsome PN.  2016.  Liver regeneration - mechanisms and models to clinical application.Nat Rev Gastroenterol Hepatol. 13(8):473-85.
Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L et al..  2016.  Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.Gut.

Pages