|Title||X chromosome inactivation in the cycle of life.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Barakat TStefan, Gribnau J|
|Date Published||2012 Jun|
|Keywords||Animals, Genomic Imprinting, Life Cycle Stages, Regulatory Sequences, Nucleic Acid, X Chromosome, X Chromosome Inactivation|
Female mammalian cells silence one of their two X chromosomes, resulting in equal expression levels of X-encoded genes in female XX and male XY cells. In mice, the X chromosomes in female cells go through sequential steps of inactivation and reactivation. Depending on the developmental time window, imprinted or random X chromosome inactivation (XCI) is initiated, and both processes lead to an inactive X chromosome that is clonally inherited. Here, we review new insights into the life cycle of XCI and provide an overview of the mechanisms regulating X inactivation and reactivation.