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X chromosome inactivation in the cycle of life.

TitleX chromosome inactivation in the cycle of life.
Publication TypeJournal Article
Year of Publication2012
AuthorsBarakat TStefan, Gribnau J
JournalDevelopment
Volume139
Issue12
Pagination2085-9
Date Published2012 Jun
ISSN1477-9129
KeywordsAnimals, Genomic Imprinting, Life Cycle Stages, Regulatory Sequences, Nucleic Acid, X Chromosome, X Chromosome Inactivation
Abstract

Female mammalian cells silence one of their two X chromosomes, resulting in equal expression levels of X-encoded genes in female XX and male XY cells. In mice, the X chromosomes in female cells go through sequential steps of inactivation and reactivation. Depending on the developmental time window, imprinted or random X chromosome inactivation (XCI) is initiated, and both processes lead to an inactive X chromosome that is clonally inherited. Here, we review new insights into the life cycle of XCI and provide an overview of the mechanisms regulating X inactivation and reactivation.

DOI10.1242/dev.069328
Alternate JournalDevelopment
PubMed ID22619385
Publication institute
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