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Tissue engineering for tendon repair.

TitleTissue engineering for tendon repair.
Publication TypeJournal Article
Year of Publication2007
AuthorsBagnaninchi PO, Yang Y, Haj AJEl, Maffulli N
JournalBr J Sports Med
Paginatione10; discussion e10
Date Published2007 Aug
KeywordsBiocompatible Materials, Female, Humans, Male, Prostheses and Implants, Reconstructive Surgical Procedures, Regeneration, Risk Factors, Sensitivity and Specificity, Stress, Mechanical, Tendinopathy, Tendon Injuries, Tendons, Tensile Strength, Tissue Engineering

Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.

Alternate JournalBr J Sports Med
PubMed ID17062654
PubMed Central IDPMC2465448
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