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Studies on blood pressure regulation in hypertensive ren-2 transgenic rats.

TitleStudies on blood pressure regulation in hypertensive ren-2 transgenic rats.
Publication TypeJournal Article
Year of Publication1992
AuthorsBarrett GL, Mullins JJ
JournalKidney Int Suppl
Date Published1992 Jun
KeywordsAnimals, Animals, Genetically Modified, Blood Pressure, Captopril, Diet, Sodium-Restricted, Hypertension, Male, Rats, Rats, Inbred Strains, Renin, Renin-Angiotensin System, Sodium

Transgenic rats harboring the mouse ren-2 gene develop severe hypertension in association with suppressed kidney and plasma renin levels. Extra-renal expression of the ren-2 gene occurs in a number of sites, and is particularly high in the adrenal cortex. We have investigated the response of blood pressure and heart rate in ren-2 rats to acute converting enzyme inhibition and to sodium depletion. In response to a single dose of captopril (1 mg/kg i.p.), blood pressure in ren-2 rats was rapidly normalized, whereas normotensive Sprague-Dawley rats were relatively unresponsive to captopril. In response to the sodium depletion protocol (five days on low-sodium diet, with furosemide administered on day 1) both ren-2 rats and normotensive Sprague-Dawley rats underwent similar initial losses of sodium followed by a gradual return to net sodium balance. Diastolic pressure in ren-2 rats fell from 160 +/- 9 mm Hg to 105 +/- 10 mm Hg after 72 hours, whereas blood pressure in Sprague-Dawley rats was essentially unchanged. The response to captopril implies a major role for angiotensin II in sustaining hypertension, and this may result from tissue generation of angiotensin I. The response to sodium depletion suggests a volume-dependent component, which may result from elevated aldosterone levels, possibly due to enhanced adrenal renin expression.

Alternate JournalKidney Int. Suppl.
PubMed ID1630068