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Segregation of the mouse germline and soma.

TitleSegregation of the mouse germline and soma.
Publication TypeJournal Article
Year of Publication2019
AuthorsZhang M, Chambers I
JournalCell Cycle
Date Published2019 Oct 04

Mouse primordial germ cells (PGCs), originate from the early post-implantation epiblast in response to BMP4 secreted by the extraembryonic ectoderm. However, how BMP4 acts here has remained unclear. Recent work has identified the transcription factor (TF), OTX2 as a key determinant of the segregation of the germline from the soma. OTX2 is expressed ubiquitously in the early post-implantation epiblast, decreasing rapidly in cells that initiate the PGC programme. mRNA is also rapidly repressed by BMP4 , in germline competent cells. Supporting a model in which BMP4 represses , enforcing sustained OTX2 expression in competent cells blocks germline entry. In contrast, -null epiblast cells enter the germline with increased efficiency and and can do so independently of BMP4. Also, -null cells can initiate germline entry even without the crucial PGC TF, BLIMP1. In this review, we survey recent advances and propose hypotheses concerning germline entry.

Alternate JournalCell Cycle
PubMed ID31583942
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