| Title | A scaleable and defined system for generating neural stem cells from human embryonic stem cells. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Joannides AJ, Fiore-Heriche C, Battersby AA, Athauda-Arachchi P, Bouhon IA, Williams L, Westmore K, Kemp PJ, Compston A, Allen ND, Chandran S |
| Journal | Stem Cells |
| Volume | 25 |
| Issue | 3 |
| Pagination | 731-7 |
| Date Published | 2007 Mar |
| ISSN | 1066-5099 |
| Keywords | Cell Differentiation, Cell Division, Cell Line, Embryonic Stem Cells, Flow Cytometry, Humans, Kinetics, Neurons |
| Abstract | The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications. |
| DOI | 10.1634/stemcells.2006-0562 |
| Alternate Journal | Stem Cells |
| PubMed ID | 17095704 |
| Grant List | G0300300 / / Medical Research Council / United Kingdom G0300331 / / Medical Research Council / United Kingdom G0600821 / / Medical Research Council / United Kingdom |
Publication institute:
Other
Printer-friendly version