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Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae.

TitleRole of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae.
Publication TypeJournal Article
Year of Publication1998
AuthorsRambukkana A, Yamada H, Zanazzi G, Mathus T, Salzer JL, Yurchenco PD, Campbell KP, Fischetti VA
JournalScience
Volume282
Issue5396
Pagination2076-9
Date Published1998 Dec 11
ISSN0036-8075
KeywordsAnimals, Bacterial Adhesion, Binding Sites, Calcium, Cell Line, Transformed, Cells, Cultured, Cytoskeletal Proteins, Dystroglycans, Edetic Acid, Glycosylation, Humans, Laminin, Membrane Glycoproteins, Mycobacterium leprae, Peripheral Nerves, Rats, Receptors, Laminin, Recombinant Fusion Proteins, Recombinant Proteins, Schwann Cells
Abstract

alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.

Alternate JournalScience
PubMed ID9851927
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