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Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination.

TitleRelapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination.
Publication TypeJournal Article
Year of Publication2013
AuthorsMünzel EJolanda, Wimperis JZ, Williams AC
JournalBMJ Case Rep
Volume2013
Date Published2013
ISSN1757-790X
KeywordsAdult, Disease Progression, Female, Humans, Immunologic Factors, Interferon-beta, Leukocyte Count, Multiple Sclerosis, Relapsing-Remitting, Neutropenia, Neutrophils
Abstract

We report the challenges of treating relapsing-remitting multiple sclerosis (MS) in a 31-year-old woman with long-standing chronic idiopathic neutropenia. The treatment with the disease-modifying therapy interferon-β was significantly complicated by a further fall in her generally low neutrophil count, to values below 0.5×10(9)/l, although this recovered rapidly when the treatment was stopped. We discuss the difficulties of balancing the risk of neutropenia with a risk of MS relapse.

DOI10.1136/bcr-2012-007936
Alternate JournalBMJ Case Rep
PubMed ID23417376