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Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats.

TitleProximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats.
Publication TypeJournal Article
Year of Publication1997
AuthorsMitchell KD, Jacinto SM, Mullins JJ
JournalAm J Physiol
Volume273
Issue2 Pt 2
PaginationF246-53
Date Published1997 Aug
ISSN0002-9513
KeywordsAngiotensin II, Animals, Animals, Genetically Modified, Body Fluids, Genes, Hypertension, Kidney, Kidney Tubules, Proximal, Male, Rats, Rats, Sprague-Dawley, Renin
Abstract

The present study was performed to assess the plasma and kidney levels of angiotensin I (ANG I) and ANG II during prehypertensive (4- to 5-wk old), development (6- to 8-wk old), and maintenance (10- to 12-wk old) phases of hypertension in pentobarbital-anesthetized transgenic rats [TGR; strain name: TGR(mRen2)27] and age-matched transgene-negative Hannover Sprague-Dawley rats (HanSD). At 4-5 wk, mean arterial pressures of TGR were not different from those of HanSD (110 +/- 5 vs. 114 +/- 4 mmHg). However, mean arterial pressures of 6-8 wk and 10-12 wk TGR were higher than those of HanSD (179 +/- 3 vs. 110 +/- 6 and 173 +/- 5 vs. 116 +/- 3 mmHg, respectively; P

Alternate JournalAm. J. Physiol.
PubMed ID9277585
Grant ListHL-50438 / HL / NHLBI NIH HHS / United States