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Pluripotent stem cell-derived hepatocytes: potential and challenges in pharmacology.

TitlePluripotent stem cell-derived hepatocytes: potential and challenges in pharmacology.
Publication TypeJournal Article
Year of Publication2013
AuthorsSzkolnicka D, Zhou W, Lucendo-Villarin B, Hay DC
JournalAnnu Rev Pharmacol Toxicol
Volume53
Pagination147-59
Date Published2013
ISSN1545-4304
KeywordsAnimals, Hepatocytes, Humans, Liver, Pluripotent Stem Cells
Abstract

The liver is a fascinating organ and performs a wide range of functions necessary for life. Because the hepatocyte is the major functional cell type found in the liver, it is important that we better understand its role in health and disease. Functional hepatocytes have been derived from many sources, including human stem cell populations. These models offer new opportunities to further our understanding of human liver biology from diverse genotypes and, in the future, to facilitate the development of novel medicines or cell-based therapies. This review discusses limitations in current cell-based models and the advantages offered by pluripotent stem cell-derived hepatocytes.

DOI10.1146/annurev-pharmtox-011112-140306
Alternate JournalAnnu. Rev. Pharmacol. Toxicol.
PubMed ID23294308
Grant List / / Medical Research Council / United Kingdom