Leading science, pioneering therapies
CRM Publications

A PLA1-2 punch regulates the Golgi complex.

TitleA PLA1-2 punch regulates the Golgi complex.
Publication TypeJournal Article
Year of Publication2012
AuthorsBechler ME, de Figueiredo P, Brown WJ
JournalTrends Cell Biol
Volume22
Issue2
Pagination116-24
Date Published2012 Feb
ISSN1879-3088
KeywordsAnimals, Endoplasmic Reticulum, Golgi Apparatus, Humans, Microtubule-Associated Proteins, Phospholipases A2, Protein Transport
Abstract

The mammalian Golgi complex, trans Golgi network (TGN) and ER-Golgi intermediate compartment (ERGIC) are comprised of membrane cisternae, coated vesicles and membrane tubules, all of which contribute to membrane trafficking and maintenance of their unique architectures. Recently, a new cast of players was discovered to regulate the Golgi and ERGIC: four unrelated cytoplasmic phospholipase A (PLA) enzymes, cPLA(2)α (GIVA cPLA(2)), PAFAH Ib (GVIII PLA(2)), iPLA(2)-β (GVIA-2 iPLA(2)) and iPLA(1)γ. These ubiquitously expressed enzymes regulate membrane trafficking from specific Golgi subcompartments, although there is evidence for some functional redundancy between PAFAH Ib and cPLA(2)α. Three of these enzymes, PAFAH Ib, cPLA(2)α and iPLA(2)-β, exert effects on Golgi structure and function by inducing the formation of membrane tubules. We review our current understanding of how PLA enzymes regulate Golgi and ERGIC morphology and function.

DOI10.1016/j.tcb.2011.10.003
Alternate JournalTrends Cell Biol.
PubMed ID22130221
PubMed Central IDPMC3273632
Grant ListDK51596 / DK / NIDDK NIH HHS / United States
R01 DK051596 / DK / NIDDK NIH HHS / United States
R01 DK051596-12 / DK / NIDDK NIH HHS / United States
R01 GM101027 / GM / NIGMS NIH HHS / United States
R56 DK051596 / DK / NIDDK NIH HHS / United States
R56 DK051596-13 / DK / NIDDK NIH HHS / United States
Publication institute
Other