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Physical forces in myelination and repair: a question of balance?

TitlePhysical forces in myelination and repair: a question of balance?
Publication TypeJournal Article
Year of Publication2009
AuthorsBauer NG, ffrench-Constant C
JournalJ Biol
Volume8
Issue8
Pagination78
Date Published2009
ISSN1475-4924
KeywordsAnimals, Cell Adhesion, Cell Shape, Extracellular Matrix, Humans, Mechanotransduction, Cellular, Multiple Sclerosis, Myelin Sheath, Regeneration
Abstract

A recent report in BMC Cell Biology examines how the balance of extracellular forces and intracellular contractions regulate the shape changes required for oligodendrocyte myelination. A failure of remyelination such as seen in multiple sclerosis could be caused by loss of this balance.

DOI10.1186/jbiol169
Alternate JournalJ. Biol.
PubMed ID19804608
PubMed Central IDPMC2776912