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[Partial removal of the mesenchyma disrupts the growth and differentiation of the epithelium in respiratory tract explants from strain A and C57BL mouse embryos].

Title[Partial removal of the mesenchyma disrupts the growth and differentiation of the epithelium in respiratory tract explants from strain A and C57BL mouse embryos].
Publication TypeJournal Article
Year of Publication1991
AuthorsKolesnichenko TS, Medvinskiĭ AL
JournalOntogenez
Volume22
Issue4
Pagination375-80
Date Published1991 Jul-Aug
ISSN0475-1450
KeywordsAnimals, Bronchi, Cell Differentiation, Epithelial Cells, Gestational Age, Mesoderm, Mice, Mice, Inbred A, Mice, Inbred C57BL, Organ Culture Techniques
Abstract

Differentiation of respiratory epithelium (E) of 17-day old embryos of A and C57BL mice after partial removal of mesenchyme (M) was studied in organ culture. In control explants, tissue-specific growth and differentiation of epithelium were observed during long-term culturing. Ih both mouse strains, partial removal of mesenchyme prevented the development of alveolar-like structures in explants of distal part of respiratory tract. In most explants of proximal part of respiratory tract (65.1% in A mice and 85.7% in C57BL mice) with partially removed mesenchyme, we found atypical epithelial structures and foci of poorly differentiated cells with high proliferation rate.

Alternate JournalOntogenez
PubMed ID1945269
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