| Title | Oct4: the final frontier, differentiation defining pluripotency. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Livigni A, Brickman JM |
| Journal | Dev Cell |
| Volume | 25 |
| Issue | 6 |
| Pagination | 547-8 |
| Date Published | 2013 Jun 24 |
| ISSN | 1878-1551 |
| Keywords | Animals, Blastocyst, Embryonic Stem Cells, Endoderm, Female, Gene Expression Regulation, Developmental, Male, Octamer Transcription Factor-3, Pregnancy |
| Abstract | The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation. |
| DOI | 10.1016/j.devcel.2013.06.002 |
| Alternate Journal | Dev. Cell |
| PubMed ID | 23806612 |
| Grant List | G0701429 / / Medical Research Council / United Kingdom |
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