Title | Oct4: the final frontier, differentiation defining pluripotency. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Livigni A, Brickman JM |
Journal | Dev Cell |
Volume | 25 |
Issue | 6 |
Pagination | 547-8 |
Date Published | 2013 Jun 24 |
ISSN | 1878-1551 |
Keywords | Animals, Blastocyst, Embryonic Stem Cells, Endoderm, Female, Gene Expression Regulation, Developmental, Male, Octamer Transcription Factor-3, Pregnancy |
Abstract | The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation. |
DOI | 10.1016/j.devcel.2013.06.002 |
Alternate Journal | Dev. Cell |
PubMed ID | 23806612 |
Grant List | G0701429 / / Medical Research Council / United Kingdom |