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New strategies to generate induced pluripotent stem cells.

TitleNew strategies to generate induced pluripotent stem cells.
Publication TypeJournal Article
Year of Publication2009
AuthorsO'Malley J, Woltjen K, Kaji K
JournalCurr Opin Biotechnol
Date Published2009 Oct
KeywordsAnimals, Cell Differentiation, Cell Separation, Fibroblasts, Humans, Induced Pluripotent Stem Cells

Direct reprogramming of somatic cells to a pluripotent state, substantiated only three years prior, is one of the most rapidly developing areas of stem cell research. The generation of patient-derived pluripotent cells applicable to disease modelling, drug screening, toxicology tests and, ultimately, autologous cell-based therapies, has the potential to revolutionize medicine. Since 2006, when Takahashi and Yamanaka first reported the generation of induced pluripotent stem cells from murine fibroblasts via retroviral transduction of a defined set of transcription factors, various new methods have been developed to refine and improve reprogramming technology. This review focus on these evolving strategies to generate genetically unmodified or reprogramming factor-free iPSCs.

Alternate JournalCurr. Opin. Biotechnol.
PubMed ID19837580
Grant ListG0700672 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom