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Neuroprotection and repair in multiple sclerosis.

TitleNeuroprotection and repair in multiple sclerosis.
Publication TypeJournal Article
Year of Publication2012
AuthorsFranklin RJM, ffrench-Constant C, Edgar JM, Smith KJ
JournalNat Rev Neurol
Volume8
Issue11
Pagination624-34
Date Published2012 Nov 5
ISSN1759-4766
KeywordsAnimals, Axons, Humans, Multiple Sclerosis, Nerve Fibers, Myelinated, Nerve Regeneration, Neuroprotective Agents, Sodium Channel Blockers
Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many people to have an autoimmune aetiology. In recent years, new data emerging from histopathology, imaging and other studies have expanded our understanding of the disease and may change the way in which it is treated. Conceptual shifts have included: first, an appreciation of the extent to which the neuron and its axon are affected in MS, and second, elucidation of how the neurobiology of axon-glial and, particularly, axon-myelin interaction may influence disease progression. In this article, we review advances in both areas, focusing on the molecular mechanisms underlying axonal loss in acute inflammation and in chronic demyelination, and discussing how the restoration of myelin sheaths via the regenerative process of remyelination might prevent axon degeneration. An understanding of these processes could lead to better strategies for the prevention and treatment of axonal loss, which will ultimately benefit patients with MS.

DOI10.1038/nrneurol.2012.200
Alternate JournalNat Rev Neurol
PubMed ID23026979
Grant List079249 / / Wellcome Trust / United Kingdom
G0300336 / / Medical Research Council / United Kingdom
G0500814 / / Medical Research Council / United Kingdom
G0800784 / / Medical Research Council / United Kingdom
G0800954 / / Medical Research Council / United Kingdom