| Title | Neural differentiation of mouse embryonic stem cells. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Stavridis M, Smith AG |
| Journal | Biochem Soc Trans |
| Volume | 31 |
| Issue | Pt 1 |
| Pagination | 45-9 |
| Date Published | 2003 Feb |
| ISSN | 0300-5127 |
| Keywords | Animals, Cell Culture Techniques, Cell Differentiation, Cell Lineage, Culture Media, Embryo, Mammalian, Mice, Models, Biological, Neurons, Stem Cells, Time Factors |
| Abstract | Pluripotent embryonic stem cells can give rise to neuroectodermal derivatives in culture. This potential could be harnessed to generate neurons and glia for cell-replacement therapies in the central nervous system and for use in drug discovery. However, current methods of neural differentiation are empirical and relatively inefficient. Here, we review these methodologies and present new tools for quantification, analysis and manipulation of embryonic stem cell neural determination. |
| DOI | 10.1042/ |
| Alternate Journal | Biochem. Soc. Trans. |
| PubMed ID | 12546651 |
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