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Neural differentiation of mouse embryonic stem cells.

TitleNeural differentiation of mouse embryonic stem cells.
Publication TypeJournal Article
Year of Publication2003
AuthorsStavridis M, Smith AG
JournalBiochem Soc Trans
IssuePt 1
Date Published2003 Feb
KeywordsAnimals, Cell Culture Techniques, Cell Differentiation, Cell Lineage, Culture Media, Embryo, Mammalian, Mice, Models, Biological, Neurons, Stem Cells, Time Factors

Pluripotent embryonic stem cells can give rise to neuroectodermal derivatives in culture. This potential could be harnessed to generate neurons and glia for cell-replacement therapies in the central nervous system and for use in drug discovery. However, current methods of neural differentiation are empirical and relatively inefficient. Here, we review these methodologies and present new tools for quantification, analysis and manipulation of embryonic stem cell neural determination.

Alternate JournalBiochem. Soc. Trans.
PubMed ID12546651