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Myelin repair: the role of stem and precursor cells in multiple sclerosis.

TitleMyelin repair: the role of stem and precursor cells in multiple sclerosis.
Publication TypeJournal Article
Year of Publication2008
AuthorsChandran S, Hunt DPJ, Joannides A, Zhao C, Compston A, Franklin RJM
JournalPhilos Trans R Soc Lond B Biol Sci
Date Published2008 Jan 12
KeywordsAnimals, Demyelinating Diseases, Humans, Multiple Sclerosis, Stem Cell Transplantation, Stem Cells, Wound Healing

Multiple sclerosis is the most common potential cause of neurological disability in young adults. The disease has two distinct clinical phases, each reflecting a dominant role for separate pathological processes: inflammation drives activity during the relapsing-remitting stage and axon degeneration represents the principal substrate of progressive disability. Recent advances in disease-modifying treatments target only the inflammatory process. They are ineffective in the progressive stage, leaving the science of disease progression unsolved. Here, the requirement is for strategies that promote remyelination and prevent axonal loss. Pathological and experimental studies suggest that these processes are tightly linked, and that remyelination or myelin repair will both restore structure and protect axons. This review considers the basic and clinical biology of remyelination and the potential contribution of stem and precursor cells to enhance and supplement spontaneous remyelination.

Alternate JournalPhilos. Trans. R. Soc. Lond., B, Biol. Sci.
PubMed ID17282989
PubMed Central IDPMC2605493
Grant List689 / / Multiple Sclerosis Society / United Kingdom
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