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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.

TitleMutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.
Publication TypeJournal Article
Year of Publication1992
AuthorsMombaerts P, Clarke AR, Rudnicki MA, Iacomini J, Itohara S, Lafaille JJ, Wang L, Ichikawa Y, Jaenisch R, Hooper ML
JournalNature
Volume360
Issue6401
Pagination225-31
Date Published1992 Nov 19
ISSN0028-0836
KeywordsAnimals, Antigens, CD8, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes, Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Genes, RAG-1, Leukocyte Count, Mice, Mice, Inbred BALB C, Mice, Mutant Strains, Mice, Transgenic, Mutation, Thymus Gland
Abstract

Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.

DOI10.1038/360225a0
Alternate JournalNature
PubMed ID1359428