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Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome.

TitleMarkedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome.
Publication TypeJournal Article
Year of Publication2014
AuthorsCraig DG, Lee P, E Pryde A, Hidalgo E, Hayes PC, Wigmore SJ, Forbes SJ, Simpson KJ
JournalCase Rep Transplant
Volume2014
Pagination272498
Date Published2014
ISSN2090-6943
Abstract

Background. Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function after liver transplantation. Murine mortality following 85% hepatectomy can be reduced by the use of soluble receptor for advanced glycation end products (sRAGE) to scavenge damage-associated molecular patterns and prevent their engagement with membrane-bound RAGE. Aims. To explore serum levels of sRAGE, high-mobility group box-1 (HMGB1) protein, and other soluble inflammatory mediators in a fatal case of SFSS. Methods. Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC). Results. HMGB1 levels were markedly higher in the SFSS patient (92.1 ng/mL) compared with the ALF patients (median (IQR) 11.4 (3.7-14.8) ng/mL) and HC (1.42 (1.38-1.56) ng/mL). In contrast, sRAGE levels were lower in the SFSS patient (1.88 ng/mL) compared with the ALF patients (3.53 (2.66-12.37) ng/mL) and were similar to HC levels (1.40 (1.23-1.89) ng/mL). Conclusion. These results suggest an imbalance between pro- and anti-inflammatory innate immune pathways in SFSS. Modulation of the HMGB1-RAGE axis may represent a future therapeutic avenue in this condition.

DOI10.1155/2014/272498
Alternate JournalCase Rep Transplant
PubMed ID24600525
PubMed Central IDPMC3926239
Publication institute
CRM