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Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.

TitleInduction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.
Publication TypeJournal Article
Year of Publication1991
AuthorsRio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, Bellocq JP, Chambon P
JournalGastroenterology
Volume100
Issue2
Pagination375-9
Date Published1991 Feb
ISSN0016-5085
KeywordsBiological Markers, Colitis, Ulcerative, Crohn Disease, Estrogens, Gastric Mucosa, Gene Expression Regulation, Humans, Immunohistochemistry, Intestinal Mucosa, Neoplasm Proteins, Peptic Ulcer, Proteins, Tumor Suppressor Proteins
Abstract

The recently discovered pS2 protein is expressed under estrogen control in a subset of estrogen receptor-positive breast cancers and in an estrogen-independent manner in normal stomach mucosa. The pS2 gene belongs to a family of genes encoding peptides that contain a conserved 5-cysteine domain, the P domains. Although the function of the pS2 protein is unknown, it has been suggested that it may have cell growth stimulatory activity. We report here that expression of the pS2 gene in the digestive tract, which is normally restricted to the stomach, is strongly induced by mucosal ulcerations elsewhere in the tract, most notably in Crohn's disease. pS2 gene expression is restricted to the mucosal layers adjacent to the ulcerations, in a region where a novel epidermal growth factor-secreting cell lineage was shown to be induced by mucosal ulceration. The human hSP gene, which contains a tandem duplication of the pS2 gene P domain and is coexpressed with the pS2 gene in normal stomach mucosa but not in breast cancers, is also expressed in Crohn's disease. We suggest that pS2 gene expression may provide a useful marker for mucosal ulcerations of the digestive tract.

Alternate JournalGastroenterology
PubMed ID1985035