Leading science, pioneering therapies
CRM Publications

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.

TitleHuman embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.
Publication TypeJournal Article
Year of Publication2010
AuthorsHardingham GE, Patani R, Baxter PS, Wyllie DJ, Chandran S
JournalMol Neurobiol
Volume42
Issue1
Pagination97-102
Date Published2010 Aug
ISSN1559-1182
KeywordsBinding Sites, Cell Culture Techniques, Cytoprotection, Embryonic Stem Cells, Evolution, Molecular, Gene Expression Regulation, Developmental, Humans, Nerve Degeneration, Neurons, Signal Transduction, Species Specificity, Transcription Factors
Abstract

The capacity to generate myriad differentiated cell types, including neurons, from human embryonic stem (hES) cell lines offers great potential for developing cell-based therapies and also for increasing our understanding of human developmental mechanisms. In addition, the emerging development of this technology as an experimental tool represents a potential opportunity for neuroscientists interested in mechanisms of neuroprotection and neurodegeneration. Potentially unlimited generation of well-defined functional neurons from hES and patient-specific induced pluripotent cells offers new systems to study disease mechanisms, signalling pathways and receptor pharmacology within a human cellular environment. Such systems may help in overcoming interspecies differences. Far from replacing rodent in vivo and primary culture systems, hES and induced disease-specific pluripotent stem cell-derived neurons offer a complementary resource to overcome issues of interspecies differences, accelerate drug discovery, study of disease mechanism and provide basic insight into human neuronal physiology.

DOI10.1007/s12035-010-8136-2
Alternate JournalMol. Neurobiol.
PubMed ID20431962
PubMed Central IDPMC2948543
Grant List087491 / / Wellcome Trust / United Kingdom