Title | Human diseases with underlying defects in chromatin structure and modification. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Authors | Hendrich B, Bickmore WA |
Journal | Hum Mol Genet |
Volume | 10 |
Issue | 20 |
Pagination | 2233-42 |
Date Published | 2001 Oct 1 |
ISSN | 0964-6906 |
Keywords | Chromatin, DNA, Gene Expression Regulation, Gene Silencing, Genetic Diseases, Inborn, Histones, Humans, Molecular Conformation, Transcription, Genetic |
Abstract | Chromatin structure is important for regulating gene expression and for the proper condensation and segregation of chromosomes during cell division. Several human genetic diseases have been found to be due to mutations in genes producing proteins known or suspected to be involved in maintaining or modifying chromatin structure. Here we describe these 'chromatin diseases' and review what is known about the associated chromatin proteins in light of recent advances in the understanding of chromatin components, modification and function. |
Alternate Journal | Hum. Mol. Genet. |
PubMed ID | 11673406 |