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The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells.

TitleThe homeodomain protein Nanog and pluripotency in mouse embryonic stem cells.
Publication TypeJournal Article
Year of Publication2005
AuthorsYates A, Chambers I
JournalBiochem Soc Trans
Volume33
IssuePt 6
Pagination1518-21
Date Published2005 Dec
ISSN0300-5127
KeywordsAnimals, Cell Line, DNA-Binding Proteins, Embryo, Mammalian, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, Phosphoproteins, Pluripotent Stem Cells
Abstract

Intrinsic regulators of the pluripotency of mouse ES (embryonic stem) cells include the homeodomain proteins Oct4 and the recently identified Nanog. When overexpressed, Nanog displays the unique attribute of robustly sustaining ES cell self-renewal in the absence of the otherwise requisite extracellular stimulation by LIF (leukaemia inhibitory factor) and BMP (bone morphogenetic protein). Here, we review our current understanding of the function of Nanog in pluripotent stem cells both in vitro and in vivo.

DOI10.1042/BST20051518
Alternate JournalBiochem. Soc. Trans.
PubMed ID16246159
Grant List / / Wellcome Trust / United Kingdom