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Gene expression heterogeneities in embryonic stem cell populations: origin and function.

TitleGene expression heterogeneities in embryonic stem cell populations: origin and function.
Publication TypeJournal Article
Year of Publication2011
AuthorsArias AMartinez, Brickman JM
JournalCurr Opin Cell Biol
Volume23
Issue6
Pagination650-6
Date Published2011 Dec
ISSN1879-0410
KeywordsCell Differentiation, Cell Division, Cell Line, Embryonic Stem Cells, Gene Expression Regulation, Developmental, Hematopoietic Stem Cells, Humans
Abstract

Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.

DOI10.1016/j.ceb.2011.09.007
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID21982544
Grant ListBB/H005978/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
G0701428 / / Medical Research Council / United Kingdom
G0701429 / / Medical Research Council / United Kingdom