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Extracellular matrix and the neural stem cell niche.

TitleExtracellular matrix and the neural stem cell niche.
Publication TypeJournal Article
Year of Publication2011
AuthorsKazanis I, ffrench-Constant C
JournalDev Neurobiol
Date Published2011 Nov
KeywordsAnimals, Extracellular Matrix, Extracellular Matrix Proteins, Humans, Neural Stem Cells, Neurogenesis, Receptors, Cell Surface, Stem Cell Niche

Basal lamina is present in many stem cell niches, but we still have a poor understanding of the role of this and other extracellular matrix (ECM) components. Here, we review current knowledge regarding ECM expression and function in the neural stem cell niche, focusing on the subependymal zone of the adult CNS. An increasing complexity of ECM molecules has been described, and a number of receptors expressed on the stem cells identified. Experiments perturbing the niche using genetics or cytotoxic ablation of the rapidly dividing precursors, or using explant culture models to examine specific growth factors, have been influential in showing how changes in these ECM receptors might regulate neural stem cell behavior. However the role of changes in the matrix itself remains to be determined. The answers will be important, as they will point to the molecules required to engineer niches ex-vivo so as to provide tools for regenerative neuroscience.

Alternate JournalDev Neurobiol
PubMed ID21898854
Grant List1P2EB00706 / EB / NIBIB NIH HHS / United States
G0601744 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
/ / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom