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An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.

TitleAn experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.
Publication TypeJournal Article
Year of Publication2008
AuthorsHampton DW, Anderson J, Pryce G, Irvine K-A, Giovannoni G, Fawcett JW, Compston A, Franklin RJM, Baker D, Chandran S
JournalJ Neuroimmunol
Volume201-202
Pagination200-11
Date Published2008 Sep 15
ISSN0165-5728
KeywordsAnimals, Antigens, Axons, Disease Models, Animal, Gliosis, Mice, Mice, Biozzi, Multiple Sclerosis, Chronic Progressive, Myelin Sheath, Nerve Tissue Proteins, Neurons, Proteoglycans, Spinal Cord
Abstract

Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to its twin pathologies of inflammatory demyelination and neurodegeneration along with its multifocal and multiphasic nature. Experimental autoimmune encephalomyelitis (EAE) in Biozzi ABH mice has previously been shown to reproduce many clinical features also found in secondary progressive MS. In this study we sought to characterise the pathology of chronic EAE in ABH mice. In addition to marked gliosis, we report substantial demyelination, remyelination and axonal and neuronal loss. Together with the clinical pattern, our findings identify chronic EAE as an excellent model of secondary progressive multiple sclerosis.

DOI10.1016/j.jneuroim.2008.05.034
Alternate JournalJ. Neuroimmunol.
PubMed ID18672298
Grant List835 / / Multiple Sclerosis Society / United Kingdom
G0701476 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom
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