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Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats.

TitleEnhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats.
Publication TypeJournal Article
Year of Publication1999
AuthorsJacinto SM, Mullins JJ, Mitchell KD
JournalAm J Physiol
Volume276
Issue2 Pt 2
PaginationF315-22
Date Published1999 Feb
ISSN0002-9513
KeywordsAcetylcholine, Animals, Animals, Genetically Modified, Blood Pressure, Blood Vessels, Bradykinin, Female, Hypertension, Mice, Norepinephrine, Rats, Reference Values, Renal Circulation, Renin, Vascular Resistance, Vasoconstrictor Agents, Vasodilator Agents
Abstract

The present study was performed to evaluate renal vascular responsiveness (RVR) to ANG II in hypertensive transgenic rats [TGR; strain TGR(mRen2)27] harboring the mouse ren-2 renin gene. Renal blood flow (RBF) responses to either intravenous or intrarenal arterial administration of ANG II were assessed in pentobarbital sodium-anesthetized female heterozygous TGR (9-12 wk old) and age-matched transgene-negative Hanover Sprague-Dawley rats (HanSD). Intravenous bolus injections of 15 and 30 ng ANG II elicited dose-dependent increases in mean arterial blood pressure (AP) and decreases in RBF in both TGR and HanSD. However, the magnitude of the increases in AP was greater in TGR than in HanSD (24 +/- 1 vs. 17 +/- 2 mmHg and 33 +/- 2 vs. 25 +/- 1 mmHg, respectively, P

Alternate JournalAm. J. Physiol.
PubMed ID9950963
Grant ListHL-50438 / HL / NHLBI NIH HHS / United States