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Differential expression of translation-associated genes in benign and malignant human breast tumours.

TitleDifferential expression of translation-associated genes in benign and malignant human breast tumours.
Publication TypeJournal Article
Year of Publication1992
AuthorsAdams SM, Sharp MG, Walker RA, Brammar WJ, Varley JM
JournalBr J Cancer
Volume65
Issue1
Pagination65-71
Date Published1992 Jan
ISSN0007-0920
KeywordsAdenofibroma, Amino Acid Sequence, Base Sequence, Blotting, Northern, Breast Neoplasms, Carcinoma, Cloning, Molecular, DNA Probes, DNA, Neoplasm, Female, Gene Library, Humans, Molecular Sequence Data, Peptides, Cyclic, Poly A, Protein Biosynthesis, RNA, RNA Probes, RNA, Messenger
Abstract

The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) compared with carcinomas (malignant) of the breast. These data parallel our previous findings that the acidic ribosomal phosphoprotein P2 also has higher expression levels in the benign breast tumours (Sharp et al., 1990). In situ hybridisation has shown these genes to be expressed predominantly in the epithelium of breast tumours.

Alternate JournalBr. J. Cancer
PubMed ID1370760
PubMed Central IDPMC1977345