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A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?

TitleA developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?
Publication TypeJournal Article
Year of Publication2003
AuthorsManley NR, C Blackburn C
JournalCurr Opin Immunol
Volume15
Issue2
Pagination225-32
Date Published2003 Apr
ISSN0952-7915
KeywordsAnimals, Cell Lineage, Epithelial Cells, Mice, Models, Biological, Organogenesis, Thymus Gland
Abstract

The origins of the non-hematopoietic cell types that comprise the thymic stroma remain a topic of considerable controversy. Three recent studies, using lineage analysis and other methods to determine the developmental potential of specific cell types within the thymus, have provided strong evidence of a single endodermal origin for all thymic epithelial cells. Together with other investigations that merge immunological and developmental biology approaches, these studies have suggested a new model of thymus organogenesis, and have begun to uncover the molecular pathways that control this process.

Alternate JournalCurr. Opin. Immunol.
PubMed ID12633674
Grant ListHD 035920 / HD / NICHD NIH HHS / United States