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Comparison of cardiorespiratory reflexes in NK1 receptor knockout, heterozygous and wild-type mice in vivo.

TitleComparison of cardiorespiratory reflexes in NK1 receptor knockout, heterozygous and wild-type mice in vivo.
Publication TypeJournal Article
Year of Publication1998
AuthorsButcher JW, De Felipe C, Smith AG, Hunt SP, Paton JF
JournalJ Auton Nerv Syst
Volume69
Issue2-3
Pagination89-95
Date Published1998 Apr 30
ISSN0165-1838
KeywordsAnimals, Chemoreceptor Cells, Female, Heart, Heterozygote, Lung, Male, Mice, Mice, Knockout, Neurokinin-1 Receptor Antagonists, Piperidines, Pressoreceptors, Receptors, Neurokinin-1, Reference Values, Reflex, Respiration
Abstract

Neurokinin-1 receptors (NK1) are present within the nucleus of the solitary tract, a nucleus which plays a vital role in cardiovascular and respiratory homeostasis. We compared the efficacy of the baroreceptor and pulmonary chemoreflexes between NK1 knockout, heterozygous and wild-type urethane-anaesthetised mice. The magnitude of the baroreceptor reflex mediated bradycardia, induced by a phenylephrine induced pressor response, was significantly greater in NK1 knockout mice (P

Alternate JournalJ. Auton. Nerv. Syst.
PubMed ID9696263