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Adhesion molecules in the stem cell niche--more than just staying in shape?

TitleAdhesion molecules in the stem cell niche--more than just staying in shape?
Publication TypeJournal Article
Year of Publication2010
AuthorsMarthiens V, Kazanis I, Moss L, Long K, ffrench-Constant C
JournalJ Cell Sci
IssuePt 10
Date Published2010 May 15
KeywordsAnimals, Cadherins, Cell Nucleus Division, Humans, Integrins, Models, Biological, Stem Cell Niche, Stem Cells

The expression of adhesion molecules by stem cells within their niches is well described, but what is their function? A conventional view is that these adhesion molecules simply retain stem cells in the niche and thereby maintain its architecture and shape. Here, we review recent literature showing that this is but one of their roles, and that they have essential functions in all aspects of the stem cell-niche interaction--retention, division and exit. We also highlight from this literature evidence supporting a simple model whereby the regulation of centrosome positioning and spindle angle is regulated by both cadherins and integrins, and the differential activity of these two adhesion molecules enables the fundamental stem cell property of switching between asymmetrical and symmetrical divisions.

Alternate JournalJ. Cell. Sci.
PubMed ID20445012
PubMed Central IDPMC2864709
Grant ListG0300336 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom