Wendy Bickmore is Head of the Chromosomes and Gene Expression Section at the MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh. After an undergraduate degree in Biochemistry at Oxford, she obtained her PhD at Edinburgh University. During postdoctoral training, she became fascinated by the structure and organization of chromosomes in the nucleus and as an independent fellow of the Lister Institute of Preventive Medicine from 1991-1996 she went on to show that different human chromosomes have preferred positions in the nucleus, related to their gene content. As a tenured MRC scientist she then investigated how individual genes are organized and packaged in the nucleus and how they move in the cell cycle and during development. Current research in Wendy Bickmore’s laboratory focuses on how the spatial organization of the nucleus influences genome function in development and disease. Wendy is an EMBO member and a Fellow of the Royal Society of Edinburgh and of the Academy of Medical Sciences. She is an editor on many journals including PLoS Genetics and Cell.
- H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction 2013 - Genome Research, 23: 2053-2065 DOI: 10.1101/gr.155028.113
- FGF Signalling Regulates Chromatin Organisation during Neural Differentiation via Mechanisms that Can Be Uncoupled from Transcription 2013 - PLoS Genetics, 9:e1003614 DOI: 10.1371/journal.pgen.1003614
- Single-Cell Dynamics of Genome-Nuclear Lamina Interactions 2013 - Cell, 153: 178-192 DOI: 10.1016/j.cell.2013.02.028
- Anterior-posterior differences in HoxD chromatin topology in limb development 2012 Development. 139: 3157-3167
- Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination 2010 Molecular Cell. 38:452-464