Siddharthan Chandran

Position:

MacDonald Professor of Neurology

Telephone:

PA, Rachel Burrow: 0131 465 9519

Display email:

siddharthan.chandran@ed.ac.uk

Biography:

• Bachelor of Medicine, Southampton University
• Neurology training, National Hospital for Neurology and Neurosurgery, University College London and University of Cambridge
• PhD in developmental neurobiology, University of Cambridge (2000)
• Consultant Neurologist, University Lecturer & Fellow of King’s College, University of Cambridge
• MacDonald Professor of Neurology, University of Edinburgh (2009-present)

Additional publications:

Livesey MR, Bilican B, Qiu J, Rzechorzek N, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ. Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. J Neurosci, in press.
Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP. Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations. Neuron 2014 81:536-43.
Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura A, Carrasco M, Phatnani H, Shum C, Wilmut I, Maniatis T, Shaw CE, Finkbeiner S, Chandran S. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A 2013 110:4697-702.
Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani H, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman B, Daley GQ, Wyllie DJA, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell specific vulnerability. Proc Natl Acad Sci USA 2012 109:5803-8.
Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012 11:150-6.

Publications

2017

Genetic epidemiology of motor neuron disease-associated variants in the Scottish population. Black, Holly A., Leighton Danielle J., Cleary Elaine M., Rose Elaine, Stephenson Laura, Colville Shuna, Ross David, Warner Jon, Porteous Mary, Gorrie George H., et al. , Neurobiol Aging, 2017 Mar, Volume 51, p.178.e11-178.e20, (2017)

2016

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Qiu, Jing, McQueen Jamie, Bilican Bilada, Dando Owen, Magnani Dario, Punovuori Karolina, Selvaraj Bhuvaneish T., Livesey Matthew, Haghi Ghazal, Heron Samuel, et al. , Elife, 2016 Oct 01, Volume 5, (2016)

Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions. Cleary, Elaine M., Pal Suvankar, Azam Tara, Moore David J., Swingler Robert, Gorrie George, Stephenson Laura, Colville Shuna, Chandran S, Porteous Mary, et al. , Mol Cell Probes, 2016 Jun 7, (2016)

Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Sances, Samuel, Bruijn Lucie I., Chandran S, Eggan Kevin, Ho Ritchie, Klim Joseph R., Livesey Matt R., Lowry Emily, Macklis Jeffrey D., Rushton David, et al. , Nat Neurosci, 2016 Mar 29, Volume 16, Issue 4, p.542-53, (2016)

Adaptive preconditioning in neurological diseases - Therapeutic insights from proteostatic perturbations. Mollereau, B, Rzechorzek Nina M., Roussel B D., Sedru M, Van den Brink D, Bailly-Maitre B, Palladino F, Medinas D B., Domingos P M., Hunot S, et al. , Brain Res, 2016 Mar 2, (2016)

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition. Rzechorzek, Nina M., Connick Peter, Livesey Matthew R., Borooah Shyamanga, Patani Rickie, Burr Karen, Story David, Wyllie David J. A., Hardingham Giles E., and Chandran S , EBioMedicine, 2016 Jan, Volume 3, p.141-54, (2016)

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes. Livesey, Matthew R., Magnani Dario, Cleary Elaine M., Vasistha Navneet A., James Owain T., Selvaraj Bhuvaneish T., Burr Karen, Story David, Shaw Christopher E., Kind Peter C., et al. , Stem Cells, 2016 Jan 13, (2016)

2015

Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis. Vesterinen, Hanna M., Connick Peter, Irvine Cadi M. J., Sena Emily S., Egan Kieren J., Carmichael Gary G., Tariq Afiyah, Pavitt Sue, Chataway Jeremy, Macleod Malcolm R., et al. , PLoS One, 2015, Volume 10, Issue 4, p.e0117705, (2015)

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells Livesey, Matthew R., Magnani Dario, Hardingham Giles E., Chandran S, and Wyllie David J. A. , The Journal of Physiology, Jan-11-2015, p.n/a - n/a, (2015)

Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale Radakovic, Ratko, Stephenson Laura, Colville Shuna, Swingler Robert, Chandran S, and Abrahams Sharon , Journal of Neurology, Neurosurgery & Psychiatry, Oct-07-2016, p.jnnp-2015-310772, (2015)

Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming. Rzechorzek, Nina M., Connick Peter, Patani Rickie, Selvaraj Bhuvaneish T., and Chandran S , EBioMedicine, 2015 Jun, Volume 2, Issue 6, p.528-35, (2015)

Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale. Radakovic, Ratko, Stephenson Laura, Colville Shuna, Swingler Robert, Chandran S, and Abrahams Sharon , J Neurol Neurosurg Psychiatry, 2015 Jul 22, (2015)

Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders. Niven, Elaine, Newton Judith, Foley Jennifer, Colville Shuna, Swingler Robert, Chandran S, Bak Thomas H., and Abrahams Sharon , Amyotroph Lateral Scler Frontotemporal Degener, 2015 May 12, p.1-8, (2015)

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Bell, Karen F. S., Al-Mubarak Bashayer, Martel Marc-André, McKay Sean, Wheelan Nicola, Hasel Philip, Márkus Nóra M., Baxter Paul, Deighton Ruth F., Serio Andrea, et al. , Nat Commun, 2015, Volume 6, p.7066, (2015)

Real-time quantitative monitoring of hiPSC-based model of macular degeneration on Electric Cell-substrate Impedance Sensing microelectrodes. Gamal, W, Borooah S, Smith S, Underwood I, Srsen V, Chandran S, Bagnaninchi Pierre O., and Dhillon B , Biosens Bioelectron, 2015 Sep 15, Volume 71, p.445-55, (2015)

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Devlin, Anna-Claire, Burr Karen, Borooah Shyamanga, Foster Joshua D., Cleary Elaine M., Geti Imbisaat, Vallier Ludovic, Shaw Christopher E., Chandran S, and Miles Gareth B. , Nat Commun, 2015, Volume 6, p.5999, (2015)

2014

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. Livesey, Matthew R., Bilican Bilada, Qiu Jing, Rzechorzek Nina M., Haghi Ghazal, Burr Karen, Hardingham Giles E., Chandran S, and Wyllie David J. A. , J Neurosci, 2014 Mar 12, Volume 34, Issue 11, p.4070-5, (2014)

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Alami, Nael H., Smith Rebecca B., Carrasco Monica A., Williams Luis A., Winborn Christina S., Han Steve S. W., Kiskinis Evangelos, Winborn Brett, Freibaum Brian D., Kanagaraj Anderson, et al. , Neuron, 2014 Feb 5, Volume 81, Issue 3, p.536-43, (2014)

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. Bilican, Bilada, Livesey Matthew R., Haghi Ghazal, Qiu Jing, Burr Karen, Siller Rick, Hardingham Giles E., Wyllie David J. A., and Chandran S , PLoS One, 2014, Volume 9, Issue 1, p.e85932, (2014)

Potential disease-modifying effects of selective serotonin reuptake inhibitors in multiple sclerosis: systematic review and meta-analysis. Foley, P, Lawler A, Chandran S, and Mead G , J Neurol Neurosurg Psychiatry, 2014 Jun, Volume 85, Issue 6, p.709-10, (2014)

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones. James, Owain T., Livesey Matthew R., Qiu Jing, Dando Owen, Bilican Bilada, Haghi Ghazal, Rajan Rinku, Burr Karen, Hardingham Giles E., Chandran S, et al. , J Physiol, 2014 Aug 28, (2014)

Mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in amyotrophic lateral sclerosis. Connick, Peter, and Chandran S , Cytotherapy, 2014 Aug, Volume 16, Issue 8, p.1031-2, (2014)

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Barmada, Sami J., Serio Andrea, Arjun Arpana, Bilican Bilada, Daub Aaron, D Ando Michael, Tsvetkov Andrey, Pleiss Michael, Li Xingli, Peisach Daniel, et al. , Nat Chem Biol, 2014 Aug, Volume 10, Issue 8, p.677-85, (2014)

Thrombotic microangiopathy associated with interferon beta. Hunt, D P. J., Kavanagh David, Drummond Iain, Weller Belinda, Bellamy Chris, Overell James, Evans Stephen, Jackson Andrew, and Chandran S , N Engl J Med, 2014 Mar 27, Volume 370, Issue 13, p.1270-1, (2014)

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. Nishimura, Agnes L., Shum Carole, Scotter Emma L., Abdelgany Amr, Sardone Valentina, Wright Jamie, Lee Youn-Bok, Chen Han-Jou, Bilican Bilada, Carrasco Monica, et al. , PLoS One, 2014, Volume 9, Issue 3, p.e91269, (2014)

2013

Patterns of cognitive dysfunction in progressive MS. Connick, Peter, Chandran S, and Bak Thomas H. , Behav Neurol, 2013 Jan 1, Volume 27, Issue 3, p.259-65, (2013)

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. Gupta, Kunal, Hardingham Giles E., and Chandran S , Neurosci Lett, 2013 May 24, Volume 543, p.95-100, (2013)

Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Foley, Peter L., Vesterinen Hanna M., Laird Barry J., Sena Emily S., Colvin Lesley A., Chandran S, Macleod Malcolm R., and Fallon Marie T. , Pain, 2013 May, Volume 154, Issue 5, p.632-42, (2013)

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis. Hampton, David W., Serio Andrea, Pryce Gareth, Al-Izki Sarah, Franklin Robin Jm, Giovannoni Gavin, Baker David, and Chandran S , Acta Neuropathol Commun, 2013, Volume 1, Issue 1, p.84, (2013)

Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Reimer, Michell M., Norris Anneliese, Ohnmacht Jochen, Patani Rickie, Zhong Zhen, Dias Tatyana B., Kuscha Veronika, Scott Angela L., Chen Yu-Chia, Rozov Stanislav, et al. , Dev Cell, 2013 Jun 10, Volume 25, Issue 5, p.478-91, (2013)

Using human induced pluripotent stem cells to treat retinal disease. Borooah, S, Phillips M J., Bilican Bilada, Wright A F., Wilmut Ian, Chandran S, Gamm D, and Dhillon B , Prog Retin Eye Res, 2013 Nov, Volume 37, p.163-81, (2013)

Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time. Bilican, Bilada, Serio Andrea, Shaw Christopher E., Maniatis Tom, and Chandran S , Cell Cycle, 2013 Aug 1, Volume 12, Issue 15, p.2339-40, (2013)

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Serio, Andrea, Bilican Bilada, Barmada Sami J., Ando Dale Michael, Zhao Chen, Siller Rick, Burr Karen, Haghi Ghazal, Story David, Nishimura Agnes L., et al. , Proc Natl Acad Sci U S A, 2013 Mar 19, Volume 110, Issue 12, p.4697-702, (2013)

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. Gupta, Kunal, Chandran S, and Hardingham Giles E. , Br J Clin Pharmacol, 2013 Apr, Volume 75, Issue 4, p.907-18, (2013)

2012

Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency. Hampton, David W., Innes Neill, Merkler Doron, Zhao Chao, Franklin Robin J. M., and Chandran S , Am J Pathol, 2012 May, Volume 180, Issue 5, p.1897-905, (2012)

Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases. Patani, Rickie, Sibley Christopher R., Chandran S, and Ule Jernej , Brain Res, 2012 Jun 26, Volume 1462, p.129-38, (2012)

Experimental and therapeutic opportunities for stem cells in multiple sclerosis. Patani, Rickie, and Chandran S , Int J Mol Sci, 2012, Volume 13, Issue 11, p.14470-91, (2012)

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. Gupta, Kunal, Patani Rickie, Baxter Paul S., Serio A, Story David, Tsujita T, Hayes J D., Pedersen R A., Hardingham Giles E., and Chandran S , Cell Death Differ, 2012 May, Volume 19, Issue 5, p.779-87, (2012)

Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? Thomson, Sophie R., Wishart Thomas M., Patani Rickie, Chandran S, and Gillingwater Thomas H. , J Anat, 2012 Feb, Volume 220, Issue 2, p.122-30, (2012)

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Connick, Peter, Kolappan Madhan, Crawley Charles, Webber Daniel J., Patani Rickie, Michell Andrew W., Du Ming-Qing, Luan Shi-Lu, Altmann Daniel R., Thompson Alan J., et al. , Lancet Neurol, 2012 Feb, Volume 11, Issue 2, p.150-6, (2012)

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Bilican, Bilada, Serio Andrea, Barmada Sami J., Nishimura Agnes L., Sullivan Gareth, Carrasco Monica, Phatnani Hemali P., Puddifoot Clare A., Story David, Fletcher Judy, et al. , Proc Natl Acad Sci U S A, 2012 Apr 10, Volume 109, Issue 15, p.5803-8, (2012)

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Patani, Rickie, Lewis Patrick A., Trabzuni Daniah, Puddifoot Clare A., Wyllie David J. A., Walker Robert, Smith Colin, Hardingham Giles E., Weale Michael, Hardy John, et al. , J Neurochem, 2012 Aug, Volume 122, Issue 4, p.738-51, (2012)

What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease. Bak, Thomas H., and Chandran S , Cortex, 2012 Jul, Volume 48, Issue 7, p.936-44, (2012)

2011

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Stacpoole, S R. L., Bilican Bilada, Webber D J., Luzhynskaya A, He X L., Compston A, Karadottir R, ffrench-Constant Charles, and Chandran S , Nat Protoc, 2011 Aug, Volume 6, Issue 8, p.1229-40, (2011)

Stem cells as a resource for regenerative neurology. Connick, P, Patani Rickie, and Chandran S , Pract Neurol, 2011 Feb, Volume 11, Issue 1, p.29-36, (2011)

Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Ruzov, Alexey, Tsenkina Yanina, Serio Andrea, Dudnakova Tatiana, Fletcher Judy, Bai Y, Chebotareva Tatiana, Pells Steve, Hannoun Zara, Sullivan Gareth, et al. , Cell Res, 2011 Sep, Volume 21, Issue 9, p.1332-42, (2011)

Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Patani, Rickie, Hollins A J., Wishart T M., Puddifoot Clare A., Alvarez S, de Lera A R., Wyllie D J. A., Compston D A. S., Pedersen R A., Gillingwater Thomas H., et al. , Nat Commun, 2011, Volume 2, p.214, (2011)

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Connick, Peter, Kolappan Madhan, Patani Rickie, Scott Michael A., Crawley Charles, He Xiao-Ling, Richardson Karen, Barber Kelly, Webber Daniel J., Wheeler-Kingshott Claudia A. M., et al. , Trials, 2011, Volume 12, p.62, (2011)

Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. Tan, Chin Lik, Kwok Jessica C. F., Patani Rickie, ffrench-Constant Charles, Chandran S, and Fawcett James W. , J Neurosci, 2011 Apr 27, Volume 31, Issue 17, p.6289-95, (2011)

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Bell, Karen F., Al-Mubarak Bashayer, Fowler Jill H., Baxter Paul S., Gupta Kunal, Tsujita Tadayuki, Chowdhry Sudhir, Patani Rickie, Chandran S, Horsburgh Karen, et al. , Proc Natl Acad Sci U S A, 2011 Jan 4, Volume 108, Issue 1, p.E1-2; author reply E3-4, (2011)

Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Stacpoole, S R. L., Bilican Bilada, Webber D J., Luzhynskaya A, He X L., Compston Alastair, Karadottir R, Franklin Robin J. M., and Chandran S , Cell Death Differ, 2011 Jun, Volume 18, Issue 6, p.1016-23, (2011)

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Tollervey, James R., Curk Tomaž, Rogelj Boris, Briese Michael, Cereda Matteo, Kayikci Melis, König Julian, Hortobágyi Tibor, Nishimura Agnes L., Zupunski Vera, et al. , Nat Neurosci, 2011 Apr, Volume 14, Issue 4, p.452-8, (2011)

2010

Human stem cell-derived neurons: a system to study human tau function and dysfunction. Iovino, Mariangela, Patani Rickie, Watts Colin, Chandran S, and Spillantini Maria Grazia , PLoS One, 2010, Volume 5, Issue 11, p.e13947, (2010)

Cell-mediated neuroprotection in a mouse model of human tauopathy. Hampton, David W., Webber Daniel J., Bilican Bilada, Goedert Michel, Spillantini Maria Grazia, and Chandran S , J Neurosci, 2010 Jul 28, Volume 30, Issue 30, p.9973-83, (2010)

Improving the translational hit of experimental treatments in multiple sclerosis. Vesterinen, Hanna M., Sena Emily S., ffrench-Constant Charles, Williams Anna C., Chandran S, and Macleod Malcolm R. , Mult Scler, 2010 Sep, Volume 16, Issue 9, p.1044-55, (2010)

Abnormal tau phosphorylation in primary progressive multiple sclerosis. Anderson, Jane Marian, Patani Rickie, Reynolds Richard, Nicholas Richard, Compston Alastair, Spillantini Maria Grazia, and Chandran S , Acta Neuropathol, 2010 May, Volume 119, Issue 5, p.591-600, (2010)

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Hardingham, Giles E., Patani Rickie, Baxter Paul S., Wyllie David J., and Chandran S , Mol Neurobiol, 2010 Aug, Volume 42, Issue 1, p.97-102, (2010)

Origins of gliogenic stem cell populations within adult skin and bone marrow. Hunt, D P. J., Sajic Marija, Phillips Helen, Henderson Deborah, Compston Alastair, Smith Kenneth, and Chandran S , Stem Cells Dev, 2010 Jul, Volume 19, Issue 7, p.1055-65, (2010)

2009

Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Vallier, Ludovic, Touboul Thomas, Brown Stephanie, Cho Candy, Bilican Bilada, Alexander Morgan, Cedervall Jessica, Chandran S, Ahrlund-Richter Lars, Weber Anne, et al. , Stem Cells, 2009 Nov, Volume 27, Issue 11, p.2655-66, (2009)

Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis. Anderson, Jane Marian, Patani Rickie, Reynolds Richard, Nicholas Richard, Compston Alastair, Spillantini Maria Grazia, and Chandran S , Acta Neuropathol, 2009 May, Volume 117, Issue 5, p.583-9, (2009)

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. Patani, Rickie, Compston Alastair, Puddifoot Clare A., Wyllie David J. A., Hardingham Giles E., Allen Nicholas D., and Chandran S , PLoS One, 2009, Volume 4, Issue 10, p.e7327, (2009)

Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalacia. Webber, Daniel J., van Blitterswijk Marka, and Chandran S , Am J Pathol, 2009 Dec, Volume 175, Issue 6, p.2332-42, (2009)

Multipotent skin-derived precursors: from biology to clinical translation. Hunt, D P. J., Jahoda Colin, and Chandran S , Curr Opin Biotechnol, 2009 Oct, Volume 20, Issue 5, p.522-30, (2009)

Tissue, cell and pathway engineering. Chandran, S, and Naughton Gail K. , Curr Opin Biotechnol, 2009 Oct, Volume 20, Issue 5, p.509-10, (2009)

2008

Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level. Bilican, Bilada, Fiore-Heriche Christelle, Compston Alastair, Allen Nicholas D., and Chandran S , PLoS One, 2008, Volume 3, Issue 8, p.e2863, (2008)

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. Hampton, David W., Anderson Jane, Pryce Gareth, Irvine Karen-Amanda, Giovannoni Gavin, Fawcett James W., Compston Alastair, Franklin Robin J. M., Baker David, and Chandran S , J Neuroimmunol, 2008 Sep 15, Volume 201-202, p.200-11, (2008)

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Anderson, J M., Hampton David W., Patani Rickie, Pryce G, Crowther R A., Reynolds R, ffrench-Constant Charles, Giovannoni G, Compston D A. S., Baker D, et al. , Brain, 2008 Jul, Volume 131, Issue Pt 7, p.1736-48, (2008)

Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration. Smith, Joseph R., Maguire Sean, Davis Lesley A., Alexander Morgan, Yang Fentang, Chandran S, ffrench-Constant Charles, and Pedersen Roger A. , Stem Cells, 2008 Feb, Volume 26, Issue 2, p.496-504, (2008)

Human embryonic stem cells: an experimental and therapeutic resource for neurological disease. Joannides, A J., and Chandran S , J Neurol Sci, 2008 Feb 15, Volume 265, Issue 1-2, p.84-8, (2008)

A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Hunt, D P. J., Morris Paul N., Sterling Jane, Anderson Jane A., Joannides Alexis, Jahoda Colin, Compston Alastair, and Chandran S , Stem Cells, 2008 Jan, Volume 26, Issue 1, p.163-72, (2008)

Introduction: stem cells and brain repair. Chandran, S, Caldwell Maeve, and Allen Nick , Philos Trans R Soc Lond B Biol Sci, 2008 Jan 12, Volume 363, Issue 1489, p.5-7, (2008)

Myelin repair: the role of stem and precursor cells in multiple sclerosis. Chandran, S, Hunt D P. J., Joannides Alexis, Zhao Chao, Compston Alastair, and Franklin Robin J. M. , Philos Trans R Soc Lond B Biol Sci, 2008 Jan 12, Volume 363, Issue 1489, p.171-83, (2008)

Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord. Hunt, D P. J., Irvine K A., Webber D J., Compston D A. S., Blakemore W F., and Chandran S , Cell Transplant, 2008, Volume 17, Issue 7, p.865-73, (2008)

What are the prospects of stem cell therapy for neurology? Chandran, S , BMJ, 2008, Volume 337, p.a1934, (2008)

2007

A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Joannides, Alexis J., Fiore-Heriche Christelle, Battersby Alysia A., Athauda-Arachchi Pandula, Bouhon Isabelle A., Williams Lydia, Westmore Kristine, Kemp Paul J., Compston Alastair, Allen Nicholas D., et al. , Stem Cells, 2007 Mar, Volume 25, Issue 3, p.731-7, (2007)

Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus. Webber, Daniel J., Compston Alastair, and Chandran S , Eur J Neurosci, 2007 Oct, Volume 26, Issue 7, p.1791-800, (2007)

Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Joannides, Alexis J., Webber Daniel J., Raineteau Olivier, Kelly Claire, Irvine Karen-Amanda, Watts Colin, Rosser Anne E., Kemp Paul J., Blakemore William F., Compston Alastair, et al. , Brain, 2007 May, Volume 130, Issue Pt 5, p.1263-75, (2007)

2006

A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. Majed, Henry H., Chandran S, Niclou Simone P., Nicholas Richard S., Wilkins Alastair, Wing Mark G., Rhodes Kate E., Spillantini Maria Grazia, and Compston Alastair , J Neurosci, 2006 Feb 8, Volume 26, Issue 6, p.1730-8, (2006)

Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Bouhon, Isabelle A., Joannides Alexis, Kato Hidemasa, Chandran S, and Allen Nicholas D. , Stem Cells, 2006 Aug, Volume 24, Issue 8, p.1908-13, (2006)

Astrocytes promote neurogenesis from oligodendrocyte precursor cells. Gaughwin, P M., Caldwell M A., Anderson J M., Schwiening C J., Fawcett J W., Compston D A. S., and Chandran S , Eur J Neurosci, 2006 Feb, Volume 23, Issue 4, p.945-56, (2006)

Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion. Joannides, Alexis, Fiore-Heriche Christelle, Westmore Kristine, Caldwell Maeve, Compston Alastair, Allen Nicholas D., and Chandran S , Stem Cells, 2006 Feb, Volume 24, Issue 2, p.230-5, (2006)

2005

Neural differentiation of mouse embryonic stem cells in chemically defined medium. Bouhon, Isabelle A., Kato Hidemasa, Chandran S, and Allen Nicholas D. , Brain Res Bull, 2005 Dec 15, Volume 68, Issue 1-2, p.62-75, (2005)

Neural stem cells as a potential source of oligodendrocytes for myelin repair. Chandran, S, and Compston Alastair , J Neurol Sci, 2005 Jun 15, Volume 233, Issue 1-2, p.179-81, (2005)

2004

Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Chandran, S, Compston Alastair, Jauniaux Eric, Gilson Jennifer, Blakemore William, and Svendsen Clive , Glia, 2004 Sep, Volume 47, Issue 4, p.314-24, (2004)

Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells. Joannides, Alexis, Gaughwin Phil, Schwiening Christof, Majed Henry, Sterling Jane, Compston Alastair, and Chandran S , Lancet, 2004 Jul 10-16, Volume 364, Issue 9429, p.172-8, (2004)

2003

FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Chandran, S, Kato Hidemasa, Gerreli Dianne, Compston Alastair, Svendsen Clive N., and Allen Nicholas D. , Development, 2003 Dec, Volume 130, Issue 26, p.6599-609, (2003)

Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. Wilkins, Alastair, Majed Henry, Layfield Robert, Compston Alastair, and Chandran S , J Neurosci, 2003 Jun 15, Volume 23, Issue 12, p.4967-74, (2003)

Cognitive presentation of multiple sclerosis: evidence for a cortical variant. Zarei, M, Chandran S, Compston A, and Hodges J , J Neurol Neurosurg Psychiatry, 2003 Jul, Volume 74, Issue 7, p.872-7, (2003)

Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. Joannides, Alexis, Gaughwin Phil, Scott Mike, Watt Suzanne, Compston Alastair, and Chandran S , J Hematother Stem Cell Res, 2003 Dec, Volume 12, Issue 6, p.681-8, (2003)

2002

Tuberous sclerosis presenting in late adult life. Zarei, M, Collins V P., Chandran S, Valler D, Higgins J N. P., Compston D A. S., and Yates J R. W. , J Neurol Neurosurg Psychiatry, 2002 Oct, Volume 73, Issue 4, p.436-8, (2002)

Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. Golde, Sabine, Chandran S, Brown Guy C., and Compston Alastair , J Neurochem, 2002 Jul, Volume 82, Issue 2, p.269-82, (2002)

2001

A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons. Wilkins, A, Chandran S, and Compston A , Glia, 2001 Oct, Volume 36, Issue 1, p.48-57, (2001)

1998

A new method for the rapid and long term growth of human neural precursor cells. Svendsen, C N., Borg M G. ter, Armstrong R J., Rosser A E., Chandran S, Ostenfeld T, and Caldwell M A. , J Neurosci Methods, 1998 Dec 1, Volume 85, Issue 2, p.141-52, (1998)

Regional potential for oligodendrocyte generation in the rodent embryonic spinal cord following exposure to EGF and FGF-2. Chandran, S, Svendsen C, Compston A, and Scolding N , Glia, 1998 Dec, Volume 24, Issue 4, p.382-9, (1998)

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