Kamil R Kranc

Position:

Professor of Molecular Haematology; CRUK Senior Cancer Research Fellow

Telephone:

0131 651 9568

Display email:

kamil.kranc@ed.ac.uk

Biography:

Education

2000: MD, Medical University of Silesia, Poland
2003: DPhil, Department of Biochemistry & Wellcome Trust Centre for Human Genetics, University of Oxford (with Professors Shoumo Bhattacharya & Kieran Clarke)

Appointments

2013-present: Professor of Molecular Haematology & CRUK Senior Fellow, MRC Centre for Regenerative Medicine, University of Edinburgh
2010-2013: Group Leader, Paul O'Gorman Leukaemia Research Centre, University of Glasgow
2008-2010: Beit Memorial Fellow for Medical Research, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
2007-2008: Postdoctoral Fellow in Stem Cell Biology, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford (with Professors Tariq Enver and Sten Eirik Jacobsen)
2003-2007: Postdoctoral Fellow in Immunology, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford (with Professor Lars Fugger)
1998-1999: Pre-doctoral Fellow, Department of Chemistry, University of Oxford (with Professors Christopher J. Schofield and Joseph F. Clark)

Awards

2016: Stem Cells Young Investigator Award
2013: CRUK Senior Cancer Research Fellowship, Cancer Research UK
2008: Beit Memorial Fellowship for Medical Research, The Wellcome Trust
2000: The Wellcome Prize PhD Studentship, The Wellcome Trust
2000: The Keith Murray Senior Scholarship, Lincoln College, University of Oxford

Publications

2017

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. Guitart, Amelie, Panagopoulou Theano I., Villacreces Arnaud, Vukovic Milica, Sepulveda Catarina, Allen Lewis, Carter Roderick N., van de Lagemaat Louie N., Morgan Marcos, Giles Peter, et al. , J Exp Med, 2017 Mar 06, Volume 214, Issue 3, p.719-735, (2017)

2016

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Woodward, Jessica, Taylor Gillian C., Soares Dinesh C., Boyle Shelagh, Sie Daoud, Read David, Chathoth Keerthi, Vukovic Milica, Tarrats Nuria, Jamieson David, et al. , Genes Dev, 2016 Oct 13, (2016)

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells. Karvela, Maria, Baquero Pablo, Kuntz Elodie M., Mukhopadhyay Arunima, Mitchell Rebecca, Allan Elaine K., Chan Edmond, Kranc Kamil R., Calabretta Bruno, Salomoni Paolo, et al. , Autophagy, 2016 May 11, p.1-13, (2016)

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Sinclair, Amy, Park Laura, Shah Mansi, Drotar Mark, Calaminus Simon, Hopcroft Lisa E. M., Kinstrie Ross, Guitart Amelie, Dunn Karen, Abrahams Sharon, et al. , Blood, 2016 May 24, (2016)

Adult haematopoietic stem cells lacking Hif-1α self-renew normally. Vukovic, Milica, Sepulveda Catarina, Subramani Chithra, Guitart Amelie, Mohr Jasmine, Allen Lewis, Panagopoulou Theano I., Paris J. K., Lawson Hannah, Villacreces Arnaud, et al. , Blood, 2016 Apr 8, (2016)

2015

Relieving oxidative stress in immune cells. Kranc, Kamil R., and Dzierzak Elaine , J Exp Med, 2015 Jul 27, Volume 212, Issue 8, p.1140, (2015)

Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells Kranc, Kamil R., Oliveira Daniel V., Armesilla-Diaz Alejandro, Pacheco-Leyva Ivette, Matias Ana Catarina, Escapa Ana Luisa, Subramani Chithra, Wheadon Helen, Trindade Marlene, Nichols Jennifer, et al. , STEM CELLS, Jan-03-2015, Volume 33, Issue 3, p.699 - 712, (2015)

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. Vukovic, Milica, Guitart Amelie, Sepulveda Catarina, Villacreces Arnaud, O'Duibhir Eoghan, Panagopoulou Theano I., Ivens Alasdair, Menendez-Gonzalez Juan, Iglesias Juan Manuel, Allen Lewis, et al. , J Exp Med, 2015 Dec 14, Volume 212, Issue 13, p.2223-34, (2015)

2014

Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells Gezer, Deniz, Vukovic Milica, Soga Tomoyoshi, Pollard Patrick J., and Kranc Kamil R. , STEM CELLS, Jan-06-2014, Volume 32, Issue 6, p.1390 - 1397, (2014)

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism Pollard, Patrick, Yang Ming, Su Huizhong, Soga Tomoyoshi, and Kranc Kamil R. , Hypoxia, Jan-08-2014, p.127, (2014)

2013

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Guitart, Amelie, Subramani Chithra, Armesilla-Diaz Alejandro, Smith Gillian, Sepulveda Catarina, Gezer Deniz, Vukovic Milica, Dunn Karen, Pollard Patrick, Holyoake Tessa L., et al. , Blood, 2013 Sep 5, Volume 122, Issue 10, p.1741-5, (2013)

2012

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. Calaminus, Simon D. J., Guitart Amelie, Guitart Amelie, Sinclair Amy, Schachtner Hannah, Watson Steve P., Holyoake Tessa L., Kranc Kamil R., and Machesky Laura M. , PLoS One, 2012, Volume 7, Issue 12, p.e51361, (2012)

2011

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. Mortensen, Monika, Soilleux Elizabeth J., Djordjevic Gordana, Tripp Rebecca, Lutteropp Michael, Sadighi-Akha Elham, Stranks Amanda J., Glanville Julie, Knight Samantha, Jacobsen Sten-Eirik W., et al. , J Exp Med, 2011 Mar 14, Volume 208, Issue 3, p.455-67, (2011)

2010

Hypoxia signaling in hematopoietic stem cells: a double-edged sword. Pollard, Patrick J., and Kranc Kamil R. , Cell Stem Cell, 2010 Sep 3, Volume 7, Issue 3, p.276-8, (2010)

2009

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. Harkiolaki, Maria, Holmes Samantha L., Svendsen Pia, Gregersen Jon W., Jensen Lise T., McMahon Roisin, Friese Manuel A., van Boxel Gijs, Etzensperger Ruth, Tzartos John S., et al. , Immunity, 2009 Mar 20, Volume 30, Issue 3, p.348-57, (2009)

Cited2 is an essential regulator of adult hematopoietic stem cells. Kranc, Kamil R., Schepers Hein, Rodrigues Neil P., Bamforth Simon, Villadsen Ellen, Ferry Helen, Bouriez-Jones Tiphaine, Sigvardsson Mikael, Bhattacharya Shoumo, Jacobsen Sten Eirik, et al. , Cell Stem Cell, 2009 Dec 4, Volume 5, Issue 6, p.659-65, (2009)

2006

Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Gregersen, Jon W., Kranc Kamil R., Ke Xiayi, Svendsen Pia, Madsen Lars S., Thomsen Allan Randrup, Cardon Lon R., Bell John I., and Fugger Lars , Nature, 2006 Oct 5, Volume 443, Issue 7111, p.574-7, (2006)

2005

Control of autoimmunity by "epitope theft". Kranc, Kamil R., Taylor Andrew M., Willcox Nicholas, and Fugger Lars , Trends Mol Med, 2005 Jan, Volume 11, Issue 1, p.1-4, (2005)

2003

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Kranc, Kamil R., Bamforth Simon D., Bragança José, Norbury Chris, van Lohuizen Maarten, and Bhattacharya Shoumo , Mol Cell Biol, 2003 Nov, Volume 23, Issue 21, p.7658-66, (2003)

2001

Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Bamforth, S D., Bragança J, Eloranta J J., Murdoch J N., Marques F I., Kranc Kamil R., Farza H, Henderson D J., Hurst H C., and Bhattacharya S , Nat Genet, 2001 Dec, Volume 29, Issue 4, p.469-74, (2001)

2000

Oxidative degradation of bilirubin produces vasoactive compounds. Kranc, Kamil R., Pyne G J., Tao L, Claridge T D., Harris D A., Cadoux-Hudson T A., Turnbull J J., Schofield C J., and Clark J F. , Eur J Biochem, 2000 Dec, Volume 267, Issue 24, p.7094-101, (2000)