Projects
Publications
2016
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.
Jackson, Melany, Ma Rui, A Taylor Helen, Axton Richard A., Easterbrook Jennifer, Kydonaki Maria, Olivier Emmanuel, Marenah Lamin, Stanley Edouard G., Elefanty Andrew G., et al.
, Stem Cells Transl Med, 2016 Aug, Volume 5, Issue 8, p.981-90, (2016)
Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells.
Yang, Cheng-Tao, Ma Rui, Axton Richard A., Jackson Melany, A Taylor Helen, Fidanza Antonella, Marenah Lamin, Frayne Jan, Mountford Joanne C., and Forrester Lesley M.
, Stem Cells, 2017 Jan 19, (2016)
2015
A role for mospd1 in mesenchymal stem cell proliferation and differentiation.
Kara, Madina, Axton Richard A., Jackson Melany, Ghaffari Sahar, Buerger Katrin, Watt Alistair J., A Taylor Helen, Orr Brigid, Hardy Winters R., Péault Bruno, et al.
, Stem Cells, 2015 Jul 14, (2015)
2013
SCF/KIT inhibition has a cumulative but reversible effect on the self-renewal of embryonic stem cells and on the survival of differentiating cells.
Fraser, Lindsay, A Taylor Helen, and Forrester Lesley M.
, Cell Reprogram, 2013 Aug, Volume 15, Issue 4, p.259-68, (2013)
Haematopoietic differentiation is inhibited when Notch activity is enhanced in FLK1(+) mesoderm progenitors.
Huang, Caoxin, Jackson Melany, Samuel Kay, A Taylor Helen, Lowell Sally, and Forrester Lesley M.
, Stem Cell Res, 2013 Nov, Volume 11, Issue 3, p.1273-87, (2013)
2012
Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance.
Zhuang, Lihui, Pound John D., Willems Jorine J. L. P., A Taylor Helen, Forrester Lesley M., and Gregory Christopher D.
, J Immunol Methods, 2012 Nov 30, Volume 385, Issue 1-2, p.1-14, (2012)
HOXB4 can enhance the differentiation of embryonic stem cells by modulating the hematopoietic niche.
Jackson, Melany, Axton Richard A., A Taylor Helen, Wilson Julie A., Gordon-Keylock Sabrina, Kokkaliaris Konstantinos D., Brickman Joshua M., Schulz Herbert, Hummel Oliver, Hübner Norbert, et al.
, Stem Cells, 2012 Feb, Volume 30, Issue 2, p.150-60, (2012)
2010
Induction of hematopoietic differentiation of mouse embryonic stem cells by an AGM-derived stromal cell line is not further enhanced by overexpression of HOXB4.
Gordon-Keylock, Sabrina, Jackson Melany, Huang Caoxin, Samuel Kay, Axton Richard A., Oostendorp Robert A. J., A Taylor Helen, Wilson Julie, and Forrester Lesley M.
, Stem Cells Dev, 2010 Nov, Volume 19, Issue 11, p.1687-98, (2010)
The culture of mouse embryonic stem cells and formation of embryoid bodies.
Jackson, Melany, A Taylor Helen, Jones Elizabeth A., and Forrester Lesley M.
, Methods Mol Biol, 2010, Volume 633, p.1-18, (2010)
2008
Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology.
Axton, Richard A., Wallis Julie A., A Taylor Helen, Hanks Mark, and Forrester Lesley M.
, J Cell Biochem, 2008 Mar 1, Volume 103, Issue 4, p.1171-82, (2008)
2006
The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.
Bashamboo, Anu, A Taylor Helen, Samuel Kay, Panthier Jean-Jacque, Whetton Anthony D., and Forrester Lesley M.
, J Cell Sci, 2006 Aug 1, Volume 119, Issue Pt 15, p.3039-46, (2006)
1991
Hypoxanthine phosphoribosyl transferase deficiency, haematopoiesis and fertility in the mouse.
Ansell, John D., Samuel Kay, Whittingham D G., Patek C E., Hardy K, Handyside A H., Jones K W., Muggleton-Harris A L., A Taylor Helen, and Hooper M L.
, Development, 1991 Jun, Volume 112, Issue 2, p.489-98, (1991)