Clare Blackburn

Position:

Professor of Tissue Stem Cell Biology

Telephone:

0131 651 9500

Display email:

c.blackburn@ed.ac.uk

Biography:

• 2011 - Professor of Tissue Stem Cell Biology, MRC Centre for Regenerative Medicine, The University of Edinburgh, UK
• January 2009 – August 2013 Director of the Graduate School of Biological Sciences
• 1997 – 2011 WT Career Development Fellow, LLR Senior Fellow, then LLR Senior Lecturer, Centre for Genome Research / Institute for Stem Cell Research / MRC Centre for Regenerative Medicine, The University of Edinburgh, UK
• 1995-1997 WT Advanced Training Fellow, then WT Career Development Fellow, Nuffield Department of Clinical Medicine, University of Oxford
• 1991-1994 WT Advanced Training Fellow, Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia (with Grant Morahan and Jacques Miller)
• PhD Biochemistry Imperial College London 1991

Publications

2017

Marketing of unproven stem cell-based interventions: A call to action. Sipp, Douglas, Caulfield Timothy, Kaye Jane, Barfoot Jan, C Blackburn Clare, Chan Sarah, De Luca Michele, Kent Alastair, McCabe Christopher, Munsie Megan, et al. , Sci Transl Med, 2017 Jul 05, Volume 9, Issue 397, (2017)

2016

FOXN1 in thymus organogenesis and development. Vaidya, Harsh Jayesh, Leon Alberto Briones, and C Blackburn Clare , Eur J Immunol, 2016 Aug, Volume 46, Issue 8, p.1826-37, (2016)

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors. Luis, Tiago C., Luc Sidinh, Mizukami Takuo, Boukarabila Hanane, Thongjuea Supat, Woll Petter S., Azzoni Emanuele, Giustacchini Alice, Lutteropp Michael, Bouriez-Jones Tiphaine, et al. , Nat Immunol, 2016 Dec, Volume 17, Issue 12, p.1424-1435, (2016)

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. O'Neill, Kathy E., Bredenkamp Nicholas, Tischner Christin, Vaidya Harsh J., Stenhouse Frances H., Peddie Dianna, Nowell Craig S., Gaskell Terri, and C Blackburn Clare , PLoS One, 2016, Volume 11, Issue 3, p.e0151666, (2016)

Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus. Ulyanchenko, Svetlana, O'Neill Kathy E., Medley Tanya, Farley Alison M., Vaidya Harsh J., Cook Alistair M., Blair Natalie F., and C Blackburn Clare , Cell Rep, 2016 Mar 29, Volume 14, Issue 12, p.2819-32, (2016)

2015

Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance. Bredenkamp, Nicholas, Jin Xin, Liu Dong, O'Neill Kathy E., Manley Nancy R., and C Blackburn Clare , Regen Med, 2015 May, Volume 10, Issue 3, p.317-29, (2015)

2014

Long-Term Persistence of Functional Thymic Epithelial Progenitor Cells In Vivo under Conditions of Low FOXN1 Expression. Jin, Xin, Nowell Craig S., Ulyanchenko Svetlana, Stenhouse Frances H., and C Blackburn Clare , PLoS One, 2014, Volume 9, Issue 12, p.e114842, (2014)

Generation of tissue organoids by compaction reaggregation. Sheridan, Julie M., and C Blackburn Clare , Methods Mol Biol, 2014, Volume 1092, p.143-51, (2014)

Serum-free culture of mid-gestation mouse embryos: a tool for the study of endoderm-derived organs. Gordon, Julie, Moore Billie A., C Blackburn Clare, and Manley Nancy R. , Methods Mol Biol, 2014, Volume 1092, p.183-94, (2014)

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts. Bredenkamp, Nicholas, Ulyanchenko Svetlana, O'Neill Kathy E., Manley Nancy Ruth, Vaidya Harsh Jayesh, and C Blackburn Clare , Nat Cell Biol, 2014 Sep, Volume 16, Issue 9, p.902-8, (2014)

Regeneration of the aged thymus by a single transcription factor. Bredenkamp, Nicholas, Nowell Craig S., and C Blackburn Clare , Development, 2014 Apr, Volume 141, Issue 8, p.1627-37, (2014)

2013

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. Garfin, Phillip M., Min Dullei, Bryson Jerrod L., Serwold Thomas, Edris Badreddin, C Blackburn Clare, Richie Ellen R., Weinberg Kenneth I., Manley Nancy R., Sage Julien, et al. , J Exp Med, 2013 Jun 3, Volume 210, Issue 6, p.1087-97, (2013)

Dynamics of thymus organogenesis and colonization in early human development. Farley, Alison, Morris Lucy X., Vroegindeweij Eric, Depreter Marianne G. L., Vaidya Harsh Jayesh, Stenhouse Frances H., Tomlinson Simon R., Anderson Richard A., Cupedo Tom, Cornelissen Jan J., et al. , Development, 2013 May, Volume 140, Issue 9, p.2015-26, (2013)

2012

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. Luc, Sidinh, Luis Tiago C., Boukarabila Hanane, Macaulay Iain C., Buza-Vidas Natalija, Bouriez-Jones Tiphaine, Lutteropp Michael, Woll Petter S., Loughran Stephen J., Mead Adam J., et al. , Nat Immunol, 2012 Apr, Volume 13, Issue 4, p.412-9, (2012)

Changes in primary lymphoid organs with aging. Chinn, Ivan K., C Blackburn Clare, Manley Nancy R., and Sempowski Gregory D. , Semin Immunol, 2012 Oct, Volume 24, Issue 5, p.309-20, (2012)

2011

Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. Nowell, Craig S., Bredenkamp Nicholas, Tetélin Stéphanie, Jin Xin, Tischner Christin, Vaidya Harsh Jayesh, Sheridan Julie M., Stenhouse Frances H., Heussen Raphaela, Smith A G., et al. , PLoS Genet, 2011 Nov, Volume 7, Issue 11, p.e1002348, (2011)

Structure and function of the thymic microenvironment. Manley, Nancy R., Richie Ellen, C Blackburn Clare, Condie Brian Gene, and Sage Julien , Front Biosci (Landmark Ed), 2011, Volume 16, p.2461-77, (2011)

2010

Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. Liu, Zhijie, Farley Alison, Chen Lizhen, Kirby Beth J., Kovacs Christopher S., C Blackburn Clare, and Manley Nancy R. , PLoS Genet, 2010, Volume 6, Issue 12, p.e1001251, (2010)

EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Foster, Katie E., Gordon Julie, Cardenas Kim, Veiga-Fernandes Henrique, Makinen Taija, Grigorieva Elena F., Wilkinson David G., C Blackburn Clare, Richie Ellen, Manley Nancy R., et al. , Proc Natl Acad Sci U S A, 2010 Jul 27, Volume 107, Issue 30, p.13414-9, (2010)

Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells. Bonfanti, Paola, Claudinot Stéphanie, Amici Alessandro W., Farley Alison, C Blackburn Clare, and Barrandon Yann , Nature, 2010 Aug 19, Volume 466, Issue 7309, p.978-82, (2010)

2009

A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations. Sheridan, Julie M., Taoudi Samir, Medvinsky A L., and C Blackburn Clare , Genesis, 2009 May, Volume 47, Issue 5, p.346-51, (2009)

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice. Lippuner, Christoph, Paape Daniel, Paterou Athina, Brand Janko, Richardson Melville, Smith A G., Hoffmann Kirstin, Brinkmann Volker, C Blackburn Clare, and Aebischer Toni , FASEB J, 2009 Feb, Volume 23, Issue 2, p.483-91, (2009)

2008

Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+CD45+ pre-definitive HSCs. Taoudi, Samir, le Gonneau Christè, Moore Kate, Sheridan Julie M., C Blackburn Clare, Taylor Erin, and Medvinsky A L. , Cell Stem Cell, 2008 Jul 3, Volume 3, Issue 1, p.99-108, (2008)

Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. Depreter, Marianne G. L., Blair Natalie F., Gaskell Terri L., Nowell Craig S., Davern Kathleen, Pagliocca Adelina, Stenhouse Frances H., Farley Alison, Fraser Adrian, Vrana Jan, et al. , Proc Natl Acad Sci U S A, 2008 Jan 22, Volume 105, Issue 3, p.961-6, (2008)

Contribution of neural crest-derived cells in the embryonic and adult thymus. Foster, Katie, Sheridan Julie M., Veiga-Fernandes Henrique, Roderick Kathleen, Pachnis Vassilis, Adams Ralf, C Blackburn Clare, Kioussis Dimitris, and Coles Mark , J Immunol, 2008 Mar 1, Volume 180, Issue 5, p.3183-9, (2008)

2007

Thymus organogenesis and development of the thymic stroma. Nowell, Craig S., Farley Alison, and C Blackburn Clare , Methods Mol Biol, 2007, Volume 380, p.125-62, (2007)

EVA regulates thymic stromal organisation and early thymocyte development. DeMonte, Lucia, Porcellini Simona, Tafi Elisiana, Sheridan Julie M., Gordon Julie, Depreter Marianne G. L., Blair Natalie F., Panigada Maddalena, Sanvito Francesca, Merati Barbara, et al. , Biochem Biophys Res Commun, 2007 May 4, Volume 356, Issue 2, p.334-40, (2007)

2006

Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Morris, Lucy, Gordon Julie, and C Blackburn Clare , Mamm Genome, 2006 Feb, Volume 17, Issue 2, p.178-87, (2006)

Bmp4 and Noggin expression during early thymus and parathyroid organogenesis. Patel, Seema R., Gordon Julie, Mahbub Farah, C Blackburn Clare, and Manley Nancy R. , Gene Expr Patterns, 2006 Oct, Volume 6, Issue 8, p.794-9, (2006)

2005

In vivo and in vitro assays of thymic organogenesis. Gordon, Julie, Wilson Valerie, Moore-Scott Billie A., Manley Nancy R., and C Blackburn Clare , Methods Mol Med, 2005, Volume 105, p.303-10, (2005)

A critical role for lipophosphoglycan in proinflammatory responses of dendritic cells to Leishmania mexicana. Aebischer, Toni, Bennett Clare L., Pelizzola Mattia, Vizzardelli Caterina, Pavelka Norman, Urbano Matteo, Capozzoli Monica, Luchini Alessandra, Ilg Thomas, Granucci Francesca, et al. , Eur J Immunol, 2005 Feb, Volume 35, Issue 2, p.476-86, (2005)

Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function. Gomez-Escobar, Natalia, Bennett Clare L., Prieto-Lafuente Lidia, Aebischer Toni, C Blackburn Clare, and Maizels Rick M. , BMC Biol, 2005, Volume 3, p.8, (2005)

2004

Functional evidence for a single endodermal origin for the thymic epithelium. Gordon, Julie, Wilson Valerie, Blair Natalie F., Sheridan Julie M., Farley Alison, Wilson Linda, Manley Nancy R., and C Blackburn Clare , Nat Immunol, 2004 May, Volume 5, Issue 5, p.546-53, (2004)

Developing a new paradigm for thymus organogenesis. C Blackburn, Clare, and Manley Nancy R. , Nat Rev Immunol, 2004 Apr, Volume 4, Issue 4, p.278-89, (2004)

2003

Uncompromised generation of a specific H-2DM-dependent peptide-MHC class II complex from exogenous antigen in Leishmania mexicana-infected dendritic cells. Bennett, Clare L., Colledge Lisa, Richards Hannah E., Reay Philip A., C Blackburn Clare, and Aebischer Toni , Eur J Immunol, 2003 Dec, Volume 33, Issue 12, p.3504-13, (2003)

New serum-free in vitro culture technique for midgestation mouse embryos. Moore-Scott, Billie A., Gordon Julie, C Blackburn Clare, Condie Brian Gene, and Manley Nancy R. , Genesis, 2003 Mar, Volume 35, Issue 3, p.164-8, (2003)

A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from? Manley, Nancy R., and C Blackburn Clare , Curr Opin Immunol, 2003 Apr, Volume 15, Issue 2, p.225-32, (2003)

2002

Rapid constitutive generation of a specific peptide-MHC class II complex from intact exogenous protein in immature murine dendritic cells. Colledge, Lisa, Bennett Clare L., Reay Philip A., and C Blackburn Clare , Eur J Immunol, 2002 Nov, Volume 32, Issue 11, p.3246-55, (2002)

2001

Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes. Bennett, Clare L., Misslitz A, Colledge L, Aebischer Toni, and C Blackburn Clare , Eur J Immunol, 2001 Mar, Volume 31, Issue 3, p.876-83, (2001)

Effect of localized cytokine dysregulation: accelerated rejection of IL-2-expressing skin grafts. C Blackburn, Clare, Grogan J L., Augustine C L., Miller J F., Varigos G, and Morahan G , Immunol Cell Biol, 2001 Apr, Volume 79, Issue 2, p.128-31, (2001)

Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch. Gordon, J, Bennett A R., C Blackburn Clare, and Manley Nancy R. , Mech Dev, 2001 May, Volume 103, Issue 1-2, p.141-3, (2001)

Differing processing requirements of four recombinant antigens containing a single defined T-cell epitope for presentation by major histocompatibility complex class II. Colledge, L, Sun M Y., Lin W, C Blackburn Clare, and Reay Philip A. , Immunology, 2001 Jul, Volume 103, Issue 3, p.343-50, (2001)

Search form

Projects