CRM Publications

Thomson JP, Ottaviano R, Unterberger EB, Lempiäinen H, Muller A, Terranova R, Illingworth R, Webb S, Kerr ARW, Lyall MJ et al..  2016.  Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.Cancer Res. 76(10):3097-108.

Diffner E, Beck D, Gudgin E, Thoms JAI, Knezevic K, Pridans C, Foster S, Goode D, Lim WKhong, Boelen L et al..  2013.  Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.Blood. 121(12):2289-300.

Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I et al..  2012.  Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.Genes Dev. 26(13):1445-58.

Spensberger D, Kotsopoulou E, Ferreira R, Broccardo C, Scott LM, Fourouclas N, Ottersbach K, Green AR, Göttgens B.  2012.  Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Exp Hematol. 40(7):588-598.e1.

Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, S Oram H, Smethurst PA, Wilson NK et al..  2011.  Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Dev Cell. 20(5):597-609.

Göttgens B, Ferreira R, Sanchez M-J, Ishibashi S, Li J, Spensberger D, Lefevre P, Ottersbach K, Chapman M, Kinston S et al..  2010.  cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Mol Cell Biol. 30(24):5741-51.

Wilson NK, Timms RT, Kinston SJ, Cheng Y-H, S Oram H, Landry J-R, Mullender J, Ottersbach K, Göttgens B.  2010.  Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.Mol Cell Biol. 30(15):3853-63.

Landry J-R, Kinston S, Knezevic K, de Bruijn MFTR, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K et al..  2008.  Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.Blood. 111(6):3005-14.

Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WYI, Wilson NK, Landry J-R, Wood AD, Kolb-Kokocinski A, Green AR et al..  2007.  Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.Proc Natl Acad Sci U S A. 104(45):17692-7.

Doumont G, Martoriati A, Beekman C, Bogaerts S, Mee PJ, Bureau F, Colombo E, Alcalay M, Bellefroid E, Marchesi F et al..  2005.  G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.EMBO J. 24(17):3093-103.

Robin C, Ottersbach K, de Bruijn M, Ma X, van der Horn K, Dzierzak E.  2003.  Developmental origins of hematopoietic stem cells.Oncol Res. 13(6-10):315-21.

Wilkins A, Majed H, Layfield R, Compston A, Chandran S.  2003.  Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor.J Neurosci. 23(12):4967-74.

Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S.  2003.  Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.Mol Cell Biol. 23(21):7658-66.

Aubert J, Dunstan H, Chambers I, Smith A.  2002.  Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.Nat Biotechnol. 20(12):1240-5.

Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A.  1998.  Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.Cell. 95(3):379-91.

Kojima N, Wang J, Mansuy IM, Grant SG, Mayford M, Kandel ER.  1997.  Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene.Proc Natl Acad Sci U S A. 94(9):4761-5.

Grant SG, Karl KA, Kiebler MA, Kandel ER.  1995.  Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.Genes Dev. 9(15):1909-21.

Zmuidzinas A, Fischer KD, Lira SA, Forrester LM, Bryant S, Bernstein A, Barbacid M.  1995.  The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.EMBO J. 14(1):1-11.

Domen J, van der Lugt NM, Laird PW, Saris C, Clarke AR, Hooper ML, Berns A.  1993.  Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells.Blood. 82(5):1445-52.