CRM Publications

Holmqvist S, Brouwer M, Djelloul M, Diaz AGarcia, Devine MJ, Hammarberg A, Fog K, Kunath T, Roybon L.  2015.  Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors.Stem Cell Res. 15(1):203-20.

Kranc KR, Dzierzak E.  2015.  Relieving oxidative stress in immune cells.J Exp Med. 212(8):1140.

Szkolnicka D, Farnworth SL, Lucendo-Villarin B, Storck C, Zhou W, Iredale JP, Flint O, Hay DC.  2014.  Accurate prediction of Drug Induced Liver Injury using stem cell-derived populations.Stem Cells Transl Med. 3(2):141-8.

Tsakiridis A, Huang Y, Blin G, Skylaki S, Wymeersch FJ, Osorno R, Economou C, Karagianni E, Zhao S, Lowell S et al..  2014.  Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.Development. 141(6):1209-21.

Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJA.  2014.  Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.J Neurosci. 34(11):4070-5.

Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJA, Chandran S.  2014.  Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.PLoS One. 9(1):e85932.

Torres-Padilla M-E, Chambers I.  2014.  Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.Development. 141(11):2173-81.

Medine C.N, Lucendo-Villarin B, Storck C, Wang F, Szkolnicka D, Khan F, Pernagallo S, Black JR, Marriage HM, Ross JA et al..  2013.  Developing high-fidelity hepatotoxicity models from pluripotent stem cells.Stem Cells Transl Med. 2(7):505-9.

Greenhough S, Bradburn H, Gardner J, Hay DC.  2013.  Development of an embryoid body-based screening strategy for assessing the hepatocyte differentiation potential of human embryonic stem cells following single-cell dissociation.Cell Reprogram. 15(1):9-14.

Zhou X, Smith AG, Waterhouse A, Blin G, Malaguti M, Lin C-Y, Osorno R, Chambers I, Lowell S.  2013.  Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.Stem Cells. 31(8):1511-22.

Gupta K, Chandran S, Hardingham GE.  2013.  Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.Br J Clin Pharmacol. 75(4):907-18.

de Wit E, Bouwman BAM, Zhu Y, Klous P, Splinter E, Verstegen MJAM, Krijger PHL, Festuccia N, Nora EP, Welling M et al..  2013.  The pluripotent genome in three dimensions is shaped around pluripotency factors.Nature. 501(7466):227-31.

Szkolnicka D, Zhou W, Lucendo-Villarin B, Hay DC.  2013.  Pluripotent stem cell-derived hepatocytes: potential and challenges in pharmacology.Annu Rev Pharmacol Toxicol. 53:147-59.

Hay DC.  2013.  Rapid and scalable human stem cell differentiation: now in 3D.Stem Cells Dev. 22(20):2691-2.

Karwacki-Neisius V, Göke J, Osorno R, Halbritter F, Ng JHui, Weiße AY, Wong F, Gagliardi A, Mullin NP, Festuccia N et al..  2013.  Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog.Cell Stem Cell. 12(5):531-45.

Festuccia N, Osorno R, Wilson V, Chambers I.  2013.  The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states.Curr Opin Genet Dev. 23(5):504-11.

Stricker SH, Feber A, Engström PG, Carén H, Kurian KM, Takashima Y, Watts C, Way M, Dirks P, Bertone P et al..  2013.  Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.Genes Dev. 27(6):654-69.

Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I et al..  2012.  Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.Genes Dev. 26(13):1445-58.

Falk A, Koch P, Kesavan J, Takashima Y, Ladewig J, Alexander M, Wiskow O, Tailor J, Trotter M, Pollard SM et al..  2012.  Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.PLoS One. 7(1):e29597.

Osorno R, Tsakiridis A, Wong F, Cambray N, Economou C, Wilkie R, Blin G, Scotting PJ, Chambers I, Wilson V.  2012.  The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression.Development. 139(13):2288-98.

Festuccia N, Osorno R, Halbritter F, Karwacki-Neisius V, Navarro P, Colby D, Wong F, Yates A, Tomlinson SR, Chambers I.  2012.  Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells.Cell Stem Cell. 11(4):477-90.

Soufi A, Donahue G, Zaret KS.  2012.  Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome.Cell. 151(5):994-1004.

Lynch MD, Smith AG, De Gobbi M, Flenley M, Hughes J, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L et al..  2012.  An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.EMBO J. 31(2):317-29.

Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJA, Walker R, Smith C, Hardingham GE, Weale M, Hardy J et al..  2012.  Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.J Neurochem. 122(4):738-51.

Navarro P, Festuccia N, Colby D, Gagliardi A, Mullin NP, Zhang W, Karwacki-Neisius V, Osorno R, Kelly D, Robertson M et al..  2012.  OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.EMBO J. 31(24):4547-62.