Leading science, pioneering therapies
How to make a stem cell: Notch and TGFbsignalling crosstalk in the haemogenic endothelium

How to make a stem cell: Notch and TGFbsignalling crosstalk in the haemogenic endothelium

Event Date
10 March 2016 - 12:00 to 13:00
Location
SCRM Building - Large Seminar Room
Speaker Name
Dr Rui Monteiro
Speaker Organisation
Radcliffe Department of Medicine, University of Oxford, UK

Short Bio

Rui Monteiro graduated in Biochemistry in 1999 by the University of Lisbon, Portugal. He obtained his PhD in Developmental Biology by the University of Utrecht in 2005, where he has focused on the TGFband BMP pathway in mouse, producing two BMP reporter lines that are widely used by the scientific community. He has started his work in the zebrafish then and identified two zebrafish BMP type II receptors that are important in in the the process of Left-right Asymmetry. As a postdoctoral scientist at the University of Oxford, he decided to focus on the zebrafish model and started work on haematopoiesis, more specifically in lineage fate decisions of blood stem cells. Currently he is a BHF Intermediate Fellow and is investigating how TGFβ signalling regulates formation of blood stem cells from endothelial cells and are also developing tools to model human cardiovascular diseases induced by altered TGFβ signalling such as Hereditary Hemorragic Telangiectasia (HHT) or Marfan syndrome. His approach includes the use of Tol2-mediated transgenesis and genome editing tools (CRISPRs/TALENs), transcriptional profiling and genetic analysis.