Leading science, pioneering therapies

Myelination and repair in the CNS group publications

2010

Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, D Eckley M, Sasaki T, Patton B, Mattson MP et al..  2010.  Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.J Neurosci. 30(29):9771-81.

2009

Marthiens V, ffrench-Constant C.  2009.  Adherens junction domains are split by asymmetric division of embryonic neural stem cells.EMBO Rep. 10(5):515-20.
Laursen LS, Chan CW, ffrench-Constant C.  2009.  An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation.J Neurosci. 29(29):9174-85.
Câmara J, Wang Z, Nunes-Fonseca C, Friedman HC, Grove M, Sherman DL, Komiyama NH, Grant SG, Brophy PJ, Peterson A et al..  2009.  Integrin-mediated axoglial interactions initiate myelination in the central nervous system.J Cell Biol. 185(4):699-712.
Loulier K, Lathia JD, Marthiens V, Relucio J, Mughal MR, Tang S-C, Coksaygan T, Hall PE, Chigurupati S, Patton B et al..  2009.  beta1 integrin maintains integrity of the embryonic neocortical stem cell niche.PLoS Biol. 7(8):e1000176.
Bauer NG, Richter-Landsberg C, ffrench-Constant C.  2009.  Role of the oligodendroglial cytoskeleton in differentiation and myelination.Glia. 57(16):1691-705.
Zhao C, Fancy SPJ, Franklin RJM, ffrench-Constant C.  2009.  Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.J Neurosci Res. 87(15):3447-55.
Baer AS, Syed YA, Kang SUng, Mitteregger D, Vig R, ffrench-Constant C, Franklin RJM, Altmann F, Lubec G, Kotter MR.  2009.  Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.Brain. 132(Pt 2):465-81.
Bauer NG, ffrench-Constant C.  2009.  Physical forces in myelination and repair: a question of balance?J Biol. 8(8):78.

2008

Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, ffrench-Constant C, Giovannoni G, Compston DAS, Baker D et al..  2008.  Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.Brain. 131(Pt 7):1736-48.
Smith JR, Maguire S, Davis LA, Alexander M, Yang F, Chandran S, ffrench-Constant C, Pedersen RA.  2008.  Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration.Stem Cells. 26(2):496-504.
Hall PE, Lathia JD, Caldwell MA, ffrench-Constant C.  2008.  Laminin enhances the growth of human neural stem cells in defined culture media.BMC Neurosci. 9:71.
Franklin RJM, ffrench-Constant C.  2008.  Remyelination in the CNS: from biology to therapy.Nat Rev Neurosci. 9(11):839-55.
Zhao C, Fancy SPJ, ffrench-Constant C, Franklin RJM.  2008.  Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.Neurobiol Dis. 31(2):209-17.

2007

Laursen LS, ffrench-Constant C.  2007.  Adhesion molecules in the regulation of CNS myelination.Neuron Glia Biol. 3(4):367-75.

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